Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice

Document Type : Original Article


1 Department of Histology, Faculty of Medicine, Sohag University, Egypt.

2 Department of Histology, Faculty of Medicine, Sohag University, Egypt

3 Department of histology, Faculty of medicine, Sohag university.

4 2Department of surgery, Faculty of medicine, Sohaguniversity


Cirrhosis is the final stage of chronic liver disease. It is characterized by diffuse fibrosis and disruption of hepatic lobular architectureinto abnormal cirrhotic nodules.
Aim of the work
This study was conducted to investigate the extent of reticular fibersdeposition in induced liver cirrhosis and their resolution after cessation of the insult.
Materials and methods
Three groups of animals were used; control, treated and recovery groups. The treatedgroup injected subcutaneously with CCl4 for 16 weeks for induction of cirrhosis, and the recovery group were kept for two weeks without injection after the 16 weeks of CCl4 treatment.
Our results indicated thatreticular fibers increased in liver cirrhosis and decreased with fibers resolution in mice.
Reticular fibers areinvolved in the process of fibrogenesis in mice and decreased in the resolution of fibers in the recovery of the model which can be consideredin newstudies for the treatment of liver cirrhosis.


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