new protocol for subjective assessment of neurocognitive function in paediatrics

Document Type : Original Article

Authors

1 Department of Pediatrics Faculty of Medicine, University of Sohag

2 Department of Phoniatrics unit, Faculty of Medicine, Sohag University

Abstract

Introduction and aim of work Neurocognitive testing, also known as neuropsychological testing, is a performance-based method to assess cognitive functioning by comprehensive evaluation of the patient's cognitive status by specific neurologic domains ( attention, memory , judgement ,evaluation, reasoning ,computation, problem solving , decision making, comprehension and production of language(Butler et al,2013). There are many protocols for neurocognitive assessment in paediatrics; we developed new protocol for evaluation of neurocognitive function of paediatric group suitable for healthy and unhealthy children in Egyptian children. The validity and specificity were studied by application the protocol into two groups: one normal kids and the others with NHL treated with intrathecal methotrexate(Dietrich,2010)..                                                                                                    
 Patients and methods: the first step is to design the protocol for subjective evaluation of neurocognitive function. Second step is applying the protocol on two groups. The group one included 25 NHL(Non Hodgkin Lymphoma) treated children and the group two includes 10 children as controls. The third step to correlate the results with the result of standered test (StandfordBinet test 4th editions).                                                                                             
Result The design protocol is effective to evaluate the neurocognitive function and assess the minimal change as it seen obvious in the difference between the groups and the correlation with the result of StandfordBinet test.

  1. Anderson, John R (2004).Cognitive psychology and its implications (6th ed.). Worth Publishers. 519. ISBN 978-0-7167-0110-1.
  2. Buizer AI, de Sonneville LM, Veerman A (2009). Effects of chemotherapy on         neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Pediatr Blood Cancer 52:447–54.
  3. Butler RW, Fairclough DL, Katz ER (2013). Intellectual functioning and multi-dimensional attentional processes in long-term survivors of a central nervous system related pediatric malignancy. Life Sci 93(17):611-6.
  4. Carlson, Neil R (2010). Psychology: the science of behavior. Boston, Mass: Allyn& Bacon. ISBN 0-205-68557-9. OCLC 268547522.
  5. Copeland DR, Moore BD, Francis DJ, et al.2000Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study. J ClinOncol. ;14:2826–2835.
  6. Dietrich (2010). Chemotherapy associated central nervous system       damage. AdvExp Med Biol.  678:77-85.
  7. Gangjee A, Jain HD, Kurup S (2007).Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I. Anticancer Agents Med Chem 7(5):524–42.
  8. Gazdzinski LM, Cormier K, Lu FG, Lerch JP, Wong CS, Nieman BJ (2012). Radiation-induced alterations in mouse brain development characterized by magnetic resonance imaging. International Journal of Radiation Oncology, Biology, Physics.  84(5):e631–638.
  9. Kevin R. KrullRaja B KhanKirsten K. NessDavonnaLedetLiang ZhuChing-Hon PuiScott C. HowardDeo Kumar SrivastavaNoah D. SabinMelissa M. Hudson, and E. Brannon Morris 2011ped blood cancer 57(7):1191-119