Sarcoid like reaction masking Hodgkin`s lymphoma: a case report

Document Type : Case Report

Authors

1 Department of chest Diseases, Faculty of Medicine, Sohag University, Sohag, Egypt

2 chest department ,faculty of medicine. Sohag university, Sohag governorate, Egypt

Abstract

Non-caseating granulomas are a histological hallmark of sarcoidosis. Nevertheless, these tissue reactions may also be observed in lymph nodes that are associated with a malignant tumor. Sarcoid like reaction (SLR) occurs when non-caseating epithelioid cell granulomas grow in people who do not have systemic sarcoidosis. SLR has been linked to several diseases, pharmacological exposures, and malignancies. These reactions can present a clinical challenge in differentiating them from systemic sarcoidosis, increasing the risk of misdiagnosis. Sarcoid reactions cause epithelioid-cell granulomas to develop because the immune system reacts hypersensitively to antigenic elements, such as those found in tumor cells. Typically located on the lymph nodes periphery, they are rather common in malignancies, especially lymphomas. Sarcoid-like reactions (SLR) are a phenomenon that can be observed in carcinomas (4.4%), Hodgkin's disease (13.8%), and non-Hodgkin's lymphoma (7.3%). Distinguishing between systemic sarcoidosis and SLR is crucial, as the consequences of an incorrect diagnosis of sarcoidosis and a delay in the treatment of the underlying malignancy could be severe.

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Sohag Medical Journal
Volume 29, Issue 2
Clinical Science Volume
2025
Pages 65-70

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