Relationship between Ascaris lumbricoides Infection and Bronchial Asthma in Juhayna City, Sohag, Upper Egypt

Document Type : Original Article

Authors

1 Departments of Medical Parasitology, Faculty of Medicine, Sohag University

2 DepartmentFaculty of Medicine- Al-Azhar University (Assiut branch)

3 Departement of Medical Parasitology, Faculty of Medicine , Sohag University

4 Department of Medical parasitology, Faculty of Medicine,AlAzharUniversity (Assiut Branch)

5 Department of Medical Parasitology ,Faculty of Medicine , Al-Azhar University (Assiut branch)

Abstract

Bronchial asthma is a chronic inflamatory disorder of the airways characterized by airway hyperresponsiveness and reversible airflow obstruction that fluctuates over time. Parasitic infection is one of the environmental factors associated with a small increase in bronchial asthma risk. In the present study, 200 stool samples were collected from patients suffering from bronchial asthma and 200 stool samples from non-asthmatic healthy volunteers as control group. The collected samples were preserved in 10%formalin and examined macroscopically, microscopically by direct smear and formol ether sedimentation test. It was found that 12 out of 200 cases (6%) wereinfected with  Ascaris lumbricoides in asthmatic group and 2 out of 200 cases (1%) in control group with P-value = 0.007 *  indicating statistically significant difference between cases and control group

Keywords

References

  1. Anderson, G. P. (2008): “Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease,” The Lancet, 372, (9643): 1107–1119.
  2. Arshad, S.H. (2010): "Does exposure to indoor allergens contribute to the development of asthma and allergy?".Current allergy and asthma reports. 10 (1): 49–55.
  3. Cheah,J.S. and Kan,S.P.(1972):Internal Medicine  Journal Volume 2, Issue 4 November 1972 Pages 383–385.
  4. Cooper, P.; Rodrigues, L.; Cruz, A. &Barreto, M. (2009):  Asthma in Latin America: apublic health challenge and research opportunity.Allergy, 64, 5-17.
  5. Dagoye, D.; Bekele, Z.; Woldemichael, K.; Nida, H.; Yimam, M.; Hall, A.; et al.(2003): Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Am J RespirCrit Care Med. 5;167(10):1369–73.
  6. Gary, M;Manuel, E.; Lydiana, A.et al. (2007): “Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica,” Journal of Allergy and Clinical Immunology, 119, ( 3): 654–661.
  7. Hagel, I.; Lynch, N. ; Di Prisco, M.; Lopez, R. & Garcia, N. (1993):  Allergic reactivity of children of different socioeconomic levels in tropical populations. IntArchs Allergy Immunol, 101, 209-214.
  8. Hagel, I.;Cabrera, M.; Hurtado, M. ; et al. (2007):  Infection by
  9. Ascaris lumbricoides and bronchial hyper-reactivity: an outstanding association in Venezuelan school children from endemic areas. Acta Trop, 103, 231-241
  10. Hopkin, J. (2009): Immune and genetic aspects of asthma, allergy and parasitic worm infections: evolutionary links. Parasite Immunology  31(5):267-73.
  11. Hunninghake,G.M.; Soto-Quiros, M.E.; Avila, L.; et al. (2007):Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol.;119:654–661.
  12. Kay, A. (2001): Allergy and allergic diseases. First of two parts. N Engl J Med.; 344(1):30-7
  13. Kelly, F.J. and Fussell, J.C. (2011):"Air pollution and airway disease". Clinical and Experimental Allergy. 41 (8): 1059–71
  14. Leonardi-Bee, J.; Pritchard, D.and Britton, J. (2006): the Parasites in Asthma Collaboration "Asthma and Current Intestinal Parasite Infection", AJRCCM, 174 (5): 514-523.
  15. Lyle, J. Palmer; Juan, C. Celedón; Scott, T. Weiss; et al. (2002): "Ascaris lumbricoides Infection Is Associated with Increased Risk of Childhood Asthma and Atopy in Rural China", American Journal of Respiratory and Critical Care Medicine, 165 ( 11 ): 1489-1493.
  16. 16.    Martinez, F.D. (2007): "Genes, environments, development and asthma:   a reappraisal". European Respiratory Journal. 29 (1): 179–84.


 

 

Sohag Medical Journal
Volume 21, Issue 3
October 2017
Pages 61-64

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