Stem Cell Therapy

Document Type : Original Article

Authors

1 Clinical and Chemical Pathology, Faculty

2 Department of Clinical and Chemical Pathology, Faculty of Medicine, asyut University

3 Department of Clinical Pathology,Faculty of Medicine, Sohag University.

4 Department of Clinical and Chemical Pathology, Faculty of Medicine, Sohag University

5 Demonstrator of Radiology, faculty of medicine, Sohag University

Abstract

Introduction:Stem cells have an interesting history, it traces from mid of 1800 to the date, and it remains the most controversial issue of research even today. The ability of stem cells to self-renew and give rise to generations with variable degrees of differentiation capacities, offers significant potential for generation of tissues that can replace diseased and damaged ones.
Aim of the work:Aim of this essay to clarify different types and sources of stem cells and their potential uses to treat many diseases.
Conclusion:Thepotency of the stem cell specifies the differentiation potential and is an important factor that is responsible for the characteristic nature of the stem cells because of this tissue renewing capacity, stem cell researches are now one of the important cornerstones for medical research and development.

References

  1. Cruz DM, Gomes M, Reis RL, Moratal D, Salmeron-Sanchez M, Ribelles JL, et al. Differentiation of mesenchymal stem cells in chitosan scaffolds with double micro and macroporosity. J Biomed Mater Res A. 2010;95(4):1182-93.
  2. Gupta K, Chandran S, Hardingham GE. Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuropro-tective pathways and therapeutics in neurodegeneration. Br J Clin Pharmacol. 2013;75(4):907-18.
  3. Villa C, Erratico S, Razini P, Farini A, Meregalli M, Belicchi M, et al. In vivo tracking of stem cell by nanotechnologies: future prospects for mouse to human translation. Tissue Eng Part B Rev. 2011;17(1):1-11.
  4. Jeffery R, Poulsom R, Alison MR. Sources of adult hepatic stem cells: haematopoietic. Methods Mol Biol. 2009;481:141-54.
  5. Alison MR, Islam S. Attributes of adult stem cells. J Pathol. 2009;217(2):144-60.
  6. Blanpain C, Simons BD. Unravelling stem cell dynamics by lineage tracing. Nat Rev Mol Cell Biol. 2013;14(8):489-502.
  7. Gancz D, Gilboa L. Insulin and Target of rapamycin signaling orchestrate the development of ovarian niche-stem cell units in Drosophila. Development. 2013;140(20):4145-54.
  8. Gancz D, Gilboa L. Hormonal control of stem cell systems. Annu Rev Cell Dev Biol. 2013;29:137-62.
  9. Copeland N, Harris D, Gaballa MA. Human umbilical cord blood stem cells, myocardial infarction and stroke. Clin Med (Lond). 2009;9(4):342-5.
  10. Malgieri A, Kantzari E, Patrizi MP, Gambardella S. Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art. Int J Clin Exp Med. 2010;3(4):248-69.
  11. Brodsky RA, Chen AR, Dorr D, Fuchs EJ, Huff CA, Luznik L, et al. High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood. 2010;115(11):2136-41.
  12. Khoury R, Abboud MR. Stem-cell transplantation in children and adults with sickle cell disease: an update. Expert Rev Hematol. 2011;4(3):343-51.
  13. Krishnamurti L, Kharbanda S, Biernacki MA, Zhang W, Baker KS, Wagner JE, et al. Stable long-term donor engraftment following reduced-intensity hematopoietic cell transplantation for sickle cell disease. Biol Blood Marrow Transplant. 2008;14(11):1270-8.
  14. Hsieh MM, Kang EM, Fitzhugh CD, Link MB, Bolan CD, Kurlander R, et al. Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl J Med. 2009;361(24):2309-17.
  15. Hsieh MM, Fitzhugh CD, Tisdale JF. Incidence of second cancers after allogeneic hematopoietic stem cell transplantation using reduced-dose radiation. Blood. 2009;114(1):225; author reply -6.
  16. Tian H, Qu Q, Liu L, Wu D. Advances in Stem Cell Therapy for Leukemia. Curr Stem Cell Res Ther. 2016;11(2):158-65.
  17. Burnett J, Newman B, Sun D. Targeting cancer stem cells with natural products. Curr Drug Targets. 2012;13(8):1054-64.
  18. Rane SR, Kulkarni MM, Puranik SC. Chronic neutrophilic leukemia: a rare case report. Indian J Hematol Blood Transfus. 2014;30(Suppl 1):77-9.
  19. Izarra A, Moscoso I, Canon S, Carreiro C, Fondevila D, Martin-Caballero J, et al. miRNA-1 and miRNA-133a are involved in early commitment of pluripotent stem cells and demonstrate antagonistic roles in the regulation of cardiac differentiation. J Tissue Eng Regen Med. 2017;11(3):787-99.
  20. Peran M, Marchal JA, Lopez E, Jimenez-Navarro M, Boulaiz H, Rodriguez-Serrano F, et al. Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes. Cytotherapy. 2010;12(3):332-7.
  21. Armbruster C, Tevaearai H, Kleber A, Carrel T, Giraud M. Strategies to induce cardiac differentiation of Mesenchymal Stem Cells. J Stem Cells Regen Med. 2007;2(1):210-1.
  22. Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 2009;5(4):364-77.
  23. Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, et al. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol. 2009;330(2):286-304.
  24. Halban PA, German MS, Kahn SE, Weir GC. Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab. 2010;95(3):1034-43.
  25. Wu SM, Hochedlinger K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol. 2011;13(5):497-505.
  26. Dhamodaran K, Subramani M, Ponnalagu M, Shetty R, Das D. Ocular stem cells: a status update! Stem Cell Res Ther. 2014;5(2):56.
  27. Qiu X, Yang J, Liu T, Jiang Y, Le Q, Lu Y. Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells. PLoS One. 2012;7(3):e32612.
  28. Laouri M, Chen E, Looman M, Gallagher M. The burden of disease of retinal vein occlusion: review of the literature. Eye (Lond). 2011;25(8):981-8.
  29. Zacharias DG, Nelson TJ, Mueller PS, Hook CC. The science and ethics of induced pluripotency: what will become of embryonic stem cells? Mayo Clin Proc. 2011;86(7):634-40.
  30. Karakaya A, Ilkilic I. Ethical Assessment of Human Embryonic Stem Cell Research According to Turkish Muslim Scholars: First Critical Analysis and Some Reflections. Stem Cell Rev. 2016;12(4):385-93.
Sohag Medical Journal
Volume 21, Issue 3
October 2017
Pages 53-58

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