The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats

Document Type : Original Article


1 Anatomy faculty of medicine Sohag university

2 Anatomy department,assuit university,assuit,assuit


Background: Amoxicillin/clavulanic acid (AC) is used to treat a variety of bacterial infections, most frequently linked to drug-induced hepatotoxicity. Vitamin C is a necessary, water-soluble micronutrient serves as an antioxidant and cofactor for several enzymes,

Aim of the work: Our research aimed to study the potential Ameliorative role of vitamin C against the amoxicillin- clavulanic acid induced hepatotoxic effects on the liver of the adult male albino rats.

Materials and methods: 30 adult albino rats were used. The animals were equally divided into three groups, each of them consisting of 10 rats. Group I: "control" Animals were not subjected to any interference. Group II: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity. Group III: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity and Vitamin C treated it.

At the end of the experiment, blood samples and livers were collected for biochemical and histological evaluation.

Results: Administration (AC) had apparent hepatotoxic effects in the form of elevations in blood liver enzymes, disruption of the antioxidant capacity of liver tissue. Co-administration of Vitamin C could reduce all the biochemical and histological effects of AC.

Conclusion: Vitamin C a has protective and therapeutic effects on AC-induced liver damage in rats.

Keywords: liver, Amoxicillin/clavulanic acid, Vitamin C, Rats


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