Does vitamin D deficiency have a role in resistance to ovulation induction in polycystic ovary syndrome patients?

Document Type : Original Article


1 Sohag

2 sohag university ,department of obstetrics and gynecology

3 sohag university ,department of obstetrcs and gynecology

4 Obstetrics and Gynecology faculty of medicine Sohag university



vitamin D deficiency strongly predisposes to a high chance of developing polycystic ovary (pcos) women generally and specifically in resistance to ovulation induction. The frequency of vitamin D deficiency occurrence in women with PCOS ranges between 67% and 85%, with serum concentrations of 25(OH)D <20 ng/ml).

Aim and objectives: to detect the frequency of vitamin D deficiency occurrence in resistant cases of pcos, Association between body mass index and vitamin D deficiency and Impact of vitamin D supplementation on improvement of response to ovulation induction.

Patients and Methods: The research was a randomized prospective clinical trial that took place in (Obstetrics &Gynecology) department, Sohag University Hospital from November 2019 to February 2023.

Results: There was a statistically significant difference among two studied groups regarding Serum vitamin D, Signs of Ovulation, (Relation between ovulation and BMI), (Relation between pregnancy occurrence and Duration of infertility) and (Relation between pregnancy occurrence and AMH). There was no statistically significant difference among the two studied groups regarding Sociodemographics, (Period of infertility, type of infertility and phenotype of PCOS) and Laboratory investigations.

Conclusion: vitamin D deficiency occurs more frequently in resistant cases of polycystic ovary syndrome (PCOS) and represents about more than 80% of resistant cases while abot 67% of nonresistant PCOS. Vitamin D supplementation shows improvements for patients with PCOS and vitamin D deficiency in the response to ovulation induction and pregnancy rate.

Key words: vitamin D deficiency, ovulation, polycystic ovary syndrome.


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