Ali, W., Mohammed, S., Abdullah, E., Salah ElDeen, E. (2019). Aspartame: Basic Information for Toxicologists. Sohag Medical Journal, 23(2), 47-51. doi: 10.21608/smj.2019.46212
Wafaa Abdel-Ghaffar Ali; Soheir Ali Mohammed; Essam M. Abdullah; Eman Muhammad Salah ElDeen. "Aspartame: Basic Information for Toxicologists". Sohag Medical Journal, 23, 2, 2019, 47-51. doi: 10.21608/smj.2019.46212
Ali, W., Mohammed, S., Abdullah, E., Salah ElDeen, E. (2019). 'Aspartame: Basic Information for Toxicologists', Sohag Medical Journal, 23(2), pp. 47-51. doi: 10.21608/smj.2019.46212
Ali, W., Mohammed, S., Abdullah, E., Salah ElDeen, E. Aspartame: Basic Information for Toxicologists. Sohag Medical Journal, 2019; 23(2): 47-51. doi: 10.21608/smj.2019.46212
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Sohag University.
2Department of, Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Sohag University, Egypt.
3Department of pathology, Faculty of Medicine, Sohag University.
Abstract
Background: Aspartame is one of the most widely used artificial sweeteners in over 90 countries worldwide in over 6000 products, including carbonated and powdered soft drinks, hot chocolate, chewinggum, candy, desserts, yogurt, and tabletop sweeteners, as well as some pharmaceutical products like vitamins and sugar-free cough drops. Aspartame has been shown to induce oxidative stress and lipid peroxidation; most serious effects result from chronic exposure due to these effects. Also it shows organ and species toxicity with relation to the liver, kidney, brain, testis and other organs. The aim of this study is to spotlight on aspartame, the most widely used artificial sweetener regarding benefits and Hazards. This essay was conducted by reviewing the literature, researches, and textbooks dealing with aspartame. Conclusion: We found that aspartame is a good& beneficial artificial sweetener; FDA approved a safe daily dosage of 40 mg/kg/ day regarding diabetes and obesity. Harmful if used in larger doses regarding neurobehavioral, hepatic, testicular and other organ dysfunction, however it has no effects on breastfeeding or carcinogenic effects.Therfore, the role of physicians is to adjust the dose of aspartame to that which approved by FDA and do more clinical studies to detect more benefits and hazards.
1- Abhilash, M.; Paul, M.V.; Varghese, M.V.; Nair, R.H.(2011): Effect of long term intake of aspartame on antioxidant defense status in liver, Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc., 49:1203–1207.
2-Ager, D.J.; Pantaleone , D.P.; Henderson, S.A.; Katritzky, A.R.; Prakash, I.; Walters, D.E. (1998): "Commercial, Synthetic Non-nutritive Sweeteners". Angewandte Chemie International Edition, 37: (13–24): 1 Alipour, M.C. (2013): Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. J Drug Target, Early Online. 1–8. 802–1817.
3-Ashok, D.W.; Rathinasamy, S.W.(2014): Long-term effect of aspartame on the liver antioxidant status and histopathology in Wistar albino rats. Biomedicine & Preventive Nutrition. 4 (2): 299–05.
4-Budavari, S. (1989): Aspartame. The Merck Index (11th ed.). Rahway, NJ: Merck & Co. p. 859-861.
6-Choudhary, A.K. and Pretorius, E. (2017): Revisiting the safety of aspartame". Nutrition reviews. 75 (9): 718–730.
7-Darwish, A.; Eman, S.h. M.G. and El-Said (2015): Effect of N-acetylcysteine (NAC) On Hepatotoxicity of Aspartame. Egypt. J. Chem. Environ. Health, 1 (1):389-399.
9-Egbuonu, A. C. (2009): Hepatotoxic effects of low dose oral administration of monosodium glutamate in male albino rats. African Journal of Biotechnology .8 (13) 303-35.
10-Humphries, P.; Pretorius, E. and Naudé , H. (2008): Direct and indirect cellular effects of aspartame on the brain. European Journal of Clinical Nutrition. 62 (4): 451–62.
11-James, B. (2000): Mal sexual dysfunction triggered by aspartame. The spectrum (1), 11.p 8.
13-Kirkland, D. and Gatehouse, D. (2015): Aspartame: A review of genotoxicity data. Food and Chemical Toxicology. 84: 161–8.
14-Magnuson, B.A . ; Burdock , G.A . ; Doull , J . ; Kroes , R.M . ; Marsh , G . M.; Pariza, M.W.; Spencer, P.S.; Waddell, W.J.; Walker, R. and Williams G.M. (2007): Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit. Rev. Toxicol., 37(8): 629-727.
15-Marinovich, M.; Galli, C.L.; Bosetti, C.; Gallus, S.and La Vecchia, C. (2013): Aspartame, low-calorie sweeteners, and disease: regulatory safety and epidemiological issues. Food and Chemical Toxicology. 60: 109–15.
19-Ozer, J. (2008): The current state of serum biomarkers of hepatotoxicity. Toxicology. 20; 245(3):194-05.
20-Puica, C . ; Craciun, C.; Rusu, M.; Cristescu, M . ; Borsa, M . and Roman, I. (2009):Ultrastructural aspects concerning the hypothalamus-pituitary complex reactivity following chronic administration of aspartame in juvenile rats. Studia Universitatis “Vasile Goldiş” Seria Ştiințele Vieţii, 19(1), 19-24.
21-Renwick, A.G. (2006): The intake of intense sweeteners - an updated review. Food Additives and Contaminants. 23 (4): 327–38.
22-Stegink, L .D. (1987): The aspartame story: a model for the clinical testing of a food additive. The American Journal of Clinical Nutrition. 46 (1 Suppl): 204–15.
23-Stegink, L. D . ; Filer, L.J., and Baker, G.L. (1979): Plasma, erythrocyte and human milk levels of free amino acids in lactating women administered aspartame or lactose. The Journal of Nutrition. 109 (12): 2173–81.
24-Sun-Edelstein, C. and Mauskop, A . (2009): Foods and supplements in the management of migraine headaches. The Clinical Journal of Pain. 25 (5): 446–52.
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