Document Type : Review Article
Authors
1
Pediatric and neonatology department, faculty of medicine, sohag university, Sohag, Egypt
2
Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
3
Department of pediatric ,Faculty of Medicine, Sohag university.
4
Pediatric and neonatology department, faculty of medicine, Sohag university, Sohag, Egypt
Abstract
Background: Thrombosis is often underdiagnosed in neonates and toddlers. Thrombosis
primarily occurs in the pediatric demographic prior to 1 year of age and during adolescence.
Thrombosis is the abnormal formation of a clot from blood constituents within a vessel. It
results from the disruption of the complex balance of the procoagulant, anticoagulant, and
fibrinolytic systems. The morbidity and mortality rates are high, although it occurs less
frequently than adult thrombosis and does not present without a triggering event.
Objective: The aim of this review was to identify risk factors, clinical pattern, outcome of
thrombosis in children
Methods: A comprehensive search was conducted in PubMed, Google Scholar and Science
Direct, from January 2000 to September 2025, using the key words: vascular thrombosis,
arterial thrombosis, venous thrombosis, thrombophilia. The reviewers evaluated relevant
literature references as well. Only the most recent or complete study was taken into account.
Examples of articles that weren't regarded as significant scientific research include unpublished
manuscripts, oral presentations, conference abstracts, and dissertations. The lack of resources
for translation has led to the ignoring of documents written in languages other than English.
Results: Both acquired and hereditary factors contribute to the development of thrombosis.
The probability of thrombosis may increase in individuals with one or more hereditary
thrombophilia factors. Acquired factors have been shown to induce thrombosis more frequently
and effectively than inherited causes in pediatric cases. The principal factors influencing
genetic predisposition to thrombophilia are the constituents of the coagulation cascade.
Keywords
Main Subjects
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