Histological and immunohistochemical differentiation between benign and malignant mesothelial proliferation

Document Type : Review Article

Authors

1 Pathology Department, Faculty of Medicine, Sohag university

2 Department of pathology, Faculty of medicine, Sohag university

Abstract

Mesothelial proliferation is an important histopathological debate and differentiation between benign and malignant mesothelial growth is one of the challenging issues for the selection of appropriate treatment. Mesothelioma includes three histologic variants; epithelial, sarcomatous/desmoplastic and mixed. On the other hand, florid reactive hyperplasia, organizing pleuritis and entrapment of mesothelial cells are benign conditions related to mesothelium that may have many overlapping features with mesothelioma. Histological evaluation for stromal invasion or the use of immunohistochemical stains are essential to identify benign from malignant mesothelial proliferation as cytologic atypia is often not helpful because benign processes are commonly atypical and mesotheliomas are often monotonous. Causes of benign mesothelial proliferation include: infections, reaction to certain drugs, collagen vascular disease or a result of surgery, trauma, or physical injury. Unfortunately, mesothelial hyperplasia may be associated with a bronchogenic carcinoma in the lung. So tight correlation of clinical, histological and radiological investigation is essential in dealing with pleural abnormality.

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Sohag Medical Journal
Volume 29, Issue 3
Clinical Science Volume
2025
Pages 103-107

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