Comparative study between the effect of Potassium Bromate and Calcium Carbonate on the tongue and parotid gland of adult male albino rats and the possible interaction between them. (Histological and Immunohistochemical study)

Document Type : Original Article

Authors

1 Anatomy department,sohag university,sohag,sohag

2 Department of human anatomy and embryology, Faculty of Medicine, Sohag University

Abstract

Background: Potassium bromate (KBrO3) is widely used as a flour enhancer to improve dough quality and as an oxidizing agent in baked goods. An essential inorganic mineral in geological and biological processes is calcium carbonate (CaCO3) that is utilized in construction materials, cosmetics, and food.

The purpose of this study was to investigate the effects of calcium carbonate and potassium bromate on the parotid gland and tongue of adult male albino rats, as well as any potential interactions between the two.

Materials and methods: 40 male albino rats were used. The animals were equally divided into four groups. Group I "control" were given distilled water, group II were given KBrO3 at a dose of 100 mg/kg/day, group III were given CaCO3 at a dose of 50 mg/kg/ day and group IV rats were given KBrO3 then after one hour CaCO3, treatments extends for 14 days, then tongues and parotid were collected for histological study.

Results: KBrO3 caused distortion of tongue papillae, detached keratin layer, and distortion of the parotid architecture, atrophy and shrinkage of the acini, massive cytoplasmic expression of Bax in both organs. CaCO3 treatment caused no changes in both tongue and parotid with minimal expression of Bax in both. KBrO3+ CaCO3 treatment showed atrophied tongue papillae, detachment of the keratin covering, as regards the parotid there were little atrophy and shrinkage of acini with moderate Bax expression.

Conclusion: KBrO3 induced cellular damage in the rat tongue and parotid glands that can be decreased by concomitant administration of CaCO3.

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Sohag Medical Journal
Volume 29, Issue 3
Clinical Science Volume
2025
Pages 44-56

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