18 FDG PET/CT in Follow-up of Cancer Colon

Elsayed, Wafaa Abd-Elhamied; Abd Elaal, Rafat; Azouz, Mustafa; Diab, Waleed

doi:10.21608/smj.2025.384121.1573

18 FDG PET/CT in Follow-up of Cancer Colon

Document Type : Original Article

Authors

¹ department of Oncology and Nuclear Medicine,faculty of Medicine Sohag University

² department of Oncology,Sohag University,Sohag

³ department of radiology,Sohag Cancer Institute

⁴ oncology department of asusit university

10.21608/smj.2025.384121.1573

Abstract

Background: positron emission tomography-computed tomography (PET-CT) is considered a method of imaging that measures the metabolic activity of cancer cells. It is important for detecting recurrence, distant metastases, and assessment tumor response after chemotherapy and radiotherapy in patients with colorectal cancer.

Objectives: to evaluate the diagnostic value of PET/CT in detecting recurrence, and distant metastases in colorectal cancer (CRC) patients.

Materials and Methods: forty nine CRC patients referred for follow-up by PET CT after treatment at Sohag Cancer Centre. Sociodemographic and follow-up data, such as recurrence , metastasis by PET CT, were analyzed.

Results: We included 49 patients who have done PET CT. More than half of them (57.1%) were females, with a mean age of 50.63 ± 15.64. The vast majority (91.8%) of CRC pathological results were adenocarcinoma. Most patients (79.6%) received chemotherapy after surgery. The prevalence of distant LN affection was more prevalent in males (P-value = 0.045). Recurrence rate (P-value = 0.033), hepatic deposits (P-value = 0.032), and peritoneal deposits (P-value = 0.003) were significantly more prevalent in the mucinous type. Bone deposits (P-value <0.001) and free cases (P-value=0.040) were significantly more prevalent in the patients who received combined therapy. The sensitivity of PET was very high 91.7%, high specificity also 92%, positive predictive value (PPV) 91.7% , negative predictive value (NPV) 92%.

Conclusion:

FDG-PET-CT imaging is an efficient method for assessing post-treatment colorectal cancer patients with probabability of tumor recurrence or distant metastases.

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