The Possible Neuroprotective Effect Of Sesame Oil On Cerebellar Cortex Of Offspring Against Effect Of Prenatal Ingestion Of Tartrazine In Pregnant Albino Rats

Document Type : Original Article

Authors

1 Anatomy department,assuit university,assuit,assuit

2 Anatomy department,sohag university,sohag,sohag

3 Anatomy department, faculty of medicine,Sohag university

4 Human anatomy and embryology, faculty of medicine,sohag university,sohag, Egypt

Abstract

Background: Tartrazine is used worldwide as a food colorant, some of its metabolites are toxic, carcinogenic, and mutagenic. Sesame oil, derived from Sesamum indicum; contains fatty acids and phenolic compounds which are known for their antioxidant and anti-inflammatory properties.

Aim of the work: Our research aimed to study the possible protective effect of Sesame oil on the cerebellar cortex of the offspring of pregnant albino rats that received oral tartrazine during pregnancy.

Materials and methods: 24 pregnant albino rats were used. The animals were equally divided into three groups, each of them consisting of 8 rats. Group A: "control" Animals were not subjected to any treatment. Group B: were given tartrazine. Group C: were given tartrazine and sesame oil. The cerebellum of their offspring was collected for histological study at different ages.

Results: ingestion of tartrazine during pregnancy affects neurodevelopment, evidenced by histological changes in the cerebellar cortex of the offspring. Co- ingestion of Sesame oil could reduce these histological effects of tartrazine.

Conclusion: Sesame oil ingestion has protective effects against tartarazine-induced cerebellar damage in developing rats.

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Sohag Medical Journal
Volume 29, Issue 2.
Basic Science Volume
2025
Pages 13-26

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