Role of Antibodies Against Carbamylated Proteins in Early Detection of Psoriatic Arthritis Patients

Hussein, Aya M. Sherif; Abdalkareem, Mohamed Ismail; Salem, Ahmed N.M.; Radwan, Ahmed R.; Elgendy, Dalia S.; Shaban, Salma M.

doi:10.21608/smj.2025.369480.1553

Role of Antibodies Against Carbamylated Proteins in Early Detection of Psoriatic Arthritis Patients

Document Type : Original Article

Authors

¹ Department of Physical Medicine, Rheumatology & Rehabilitation, Sohag University

² Rheumatology and Rehabilitation department- Al-Azhar Faculty of Medicine- Assuit

³ Department of Clinical Pathology, Faculty of Medicine, Sohag University.

⁴ Rheumatology and Rehabilitation, Faculty of medicine , sohag university

10.21608/smj.2025.369480.1553

Abstract

Background: The most prevalent symptoms of psoriatic arthritis (PsA), a chronic musculoskeletal illness linked with psoriasis (PSO), include spondylitis, dactylitis, enthesitis, and peripheral arthritis. Even in the absence of anti-cyclic citrullinated peptide (anti-CCP) antibodies, anti-carbamylated protein (anti-CarP) was linked to joint damage in RA. This finding raised awareness of carbamylation's role in autoimmune and chronic inflammatory disorders.

Aim: To assess the role of antibodies in the early detection of PsA. Its relation to disorder activity, severity and ultrasonographic (US) findings.

Patients and Methods: Observational, comparative study on patients followed up in the Rheumatology and Rehabilitation outpatient clinic and Dermatology departments in Sohag University Hospitals, Faculty of Medicine. Thirty PsA subjects diagnosed based on the Classification Criteria of PsA study; thirty PSO patients diagnosed based on clinical examination by a dermatologist and thirty healthy subjects matching in age and sex considered as controls were included.

Results: There’s a highly considerable difference between our studied groups concerning anti-CarP abs. There is a highly significant strong positive correlation between anti-CarP abs concerning DAPSA and DAS 28. There’s a highly significant difference in anti-CarP abs regarding US findings.

Conclusion: Since anti-CarP may contribute to the pathogenesis of PsA and is a useful indicator of disease progression, it may be a promising indicator of joint dmage and disease activity in PsA patients and is associated with disease activity.

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