Document Type : Original Article
Authors
1
General surgery, merit university, sohag, egypt
2
general Surgery department, Faculty of Medicine, Sohag University, sohag, Egypt
3
General Surgery Department, Faculty of Medicine, Sohag University, Sohag; Egypt
10.21608/smj.2025.361947.1549
Abstract
Abstract
The role of prokinetic agents in the management of digestive tract disorders has garnered increasing attention in recent clinical research. This review evaluates the pharmacological mechanisms, efficacy, and clinical applications of prokinetics in gastrointestinal motility disorders, including gastroparesis, functional dyspepsia, and chronic constipation. Prokinetics, which facilitate gastrointestinal peristalsis, do so primarily through interaction with dopamine and serotonin receptors, thereby enhancing gastric emptying and intestinal motility. Various agents, such as metoclopramide, domperidone, and newer medications like prucalopride, are analyzed for their therapeutic profiles, side effects, and patient outcomes. In addition, the review discusses the importance of individualized treatment approaches, taking into consideration the underlying pathophysiology, patient comorbidities, and treatment response variability. The synthesis of current literature indicates that although prokinetics can significantly improve symptoms and quality of life in patients with motility disorders, careful selection of therapy and monitoring for potential adverse effects are crucial. Future directions for research are also highlighted, emphasizing the need for more robust clinical trials to establish the long-term safety and efficacy of these agents in diverse populations. This review aims to provide a comprehensive overview of the evolving role of prokinetics in the management of digestive tract disorders, ultimately enhancing therapeutic outcomes for affected patients.
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