Association of osteopontin promoter polymorphism and aggresivness in breast cancer

Zakhary, Madeha M.; Mahmoud, Aida A.; Ahmed, Wael B.; Hashim, Marwa Shaaban

doi:10.21608/smj.2018.42049

Association of osteopontin promoter polymorphism and aggresivness in breast cancer

Document Type : Original Article

Authors

¹ Department, of Medical Biochemistry, Faculty of Medicine, Assuit university.

² Department, of Medical Biochemistry, Faculty of Medicine, Sohag university.

³ Department of General Surgery, Faculty of Medicine, Sohag university.

⁴ Department of Biochemistry and microbiology, Facaulty of Medicine, Sohag University.

10.21608/smj.2018.42049

Abstract

Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review The role of single-nucleotide polymorphism (SNP)-443 of the OPN gene in cancer aggressiveness.

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