Red Blood Cell Distribution Width to Platelet Count Ratio as a Marker of Cardiovascular Complications in CKD Patients.

Abass, Noher Mohamad; Kassem, Ali Mahmoud; Zaki, Nayel Abdelhameed; Mohamed, Doha Ali

doi:10.21608/smj.2025.365955.1546

Red Blood Cell Distribution Width to Platelet Count Ratio as a Marker of Cardiovascular Complications in CKD Patients.

Document Type : Original Article

Authors

¹ Internal medicine department,faculty of medicine,Sohag University hospital

² Department of Internal Medicine, faculty of medicine, Sohag University, Sohag, Egypt

³ Internal medicine departement sohag university hospital.sohag.egypt

⁴ internal medicine department, faculty of medicine, Sohag university

10.21608/smj.2025.365955.1546

Abstract

Abstract:

Background: Chronic Kidney Disease (CKD) significantly increases the risk of cardiovascular complications, the leading cause of morbidity and mortality in this population. Identifying reliable biomarkers, such as the Red Blood Cell Distribution Width (RDW) to Platelet Count Ratio (RPR), could improve early intervention and management.

Aim: the aim of current study is to determine Red blood cell distribution width to platelet ratio as a marker of cardiovascular complications in CKD patients.

Methods: This observational study involved 100 CKD patients receiving dialysis at Sohag University Hospital. Data collection included medical history, clinical evaluations, and laboratory investigations. Cardiovascular assessments were conducted using electrocardiography and echocardiography. The RPR was calculated and analyzed for its correlation with cardiovascular complications.

Results: The study included 52 males and 48 females, with a mean age of 66.79 ± 9.38 years. Hematological parameters indicated a mean hemoglobin level of 10.88 ± 2.47 g/dL, WBC count of 9.813 ± 3.988 x10⁹/L, platelet count of 201.17 ± 64.84 x10⁹/L, and RDW of 14.54 ± 1.59. The mean RDW to platelet ratio was 0.07 ± 0.02. Significant correlations were observed between higher RPR and the presence of diabetes mellitus, ischemic heart disease, diastolic dysfunction, and segmental wall motion abnormalities (SWMA). ROC-curve analysis demonstrated that RPR could predict major adverse cardiac events with high specificity and positive predictive value.

Conclusion: The RDW to Platelet Count Ratio (RPR) is a significant marker of cardiovascular complications in CKD patients.

Keywords: Chronic Kidney Disease, Cardiovascular Complications, Red Blood Cell Distribution Width, Platelet Count.

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