Value of High Sensitive CRP in Hyperglycemic Patients with Acute Coronary Syndrome

Said, Alaa Ez El-Deen; Mohammed, Omar Saad; Kamal, Yasser Mohamed; El Sayed, Adel Abdel Aziz

doi:10.21608/smj.2018.41790

Value of High Sensitive CRP in Hyperglycemic Patients with Acute Coronary Syndrome

Document Type : Original Article

Authors

¹ Department of Internal Medicine, Sohag university Hospital.

² Department Internal Medicine, Sohag university Hospital.

³ Department of Internal medicine , Faculty of Medicine, Sohag University.

⁴ Department Internal Medicine , Sohag university Hospital.

10.21608/smj.2018.41790

Abstract

BACKGROUND: Hyperglycemia on admission in patients with acute coronary syndromes is common, and it is a powerful predicator of increased risk of in hospital complications in patients with and without diabetes mellitus, high sensitivity c- reactive protein (hs- CRP) is a cardiovascular risk marker in patients
with acute coronary syndrome.
OBJECTIVES:
1. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome with admission hyperglycemia whatever diabetic or not.
2. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome without admission hyperglycemia.
3. To compare the results of the above two groups and assess the prognostic value of admission glucose and hs -CRP levels in hyperglycemic patients with acute coronary syndromes.

DESIGN AND SETTING: Prospective study, at Sohag university hospital in Egypt.

METHODS: We measured the blood glucose, hs -CRP, cardiac enzymes and HBAIC levels at admission in 100 consecutive patients with ACS. Glucose was categorized as ≤11.1mmol=200 mg/dl. hs -CRP negative 3 mg, HBAIC ≤ 6.5% or ≥ 6.5).

RESULTS: In our study reveals a statistically significant relation between levels of admission glucose and left ventricular function (LV failure, pulmonary edema and cardiogenic shock) or arrhythmias in hyperglycemic patients with ACS (P< 0.0001).
Also there is a significant relation between level of hs- CRP and LVF and type of myocardial infarction in-hospital complications.
Also there is insignificant relation between HBAIC levels and left ventricular function in ACS at admission.
CONCLUSION: We conclude that elevated admission glucose appears a more important in predicting in-hospital and short term complications particularly left ventricular failure and cardiogenic shock in patients with acute coronary syndromes. Also the increased levels of hs- CRP are a predictor for severity and extent of myocardial damage and left ventricular function especially in STEMI.
The synergistic effect of associated both stress hyperglycaemia and hs- CRP is a strong predictor for poor ACS outcome.

Keywords

References

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