Comorbidity with Depression and Anxiety among Patients with Epilepsy inQena Governorate

Ahmed, Tarek Desoky; Sadek, Mohamed Abdelgwad

doi:10.21608/smj.2017.40736

Comorbidity with Depression and Anxiety among Patients with Epilepsy inQena Governorate

Document Type : Original Article

Authors

¹ department, of Psychiatry.Faculty of Medicine-Sohag University.

² Department of Neuropsychiatry, South Valley University, Qena, Egypt.

10.21608/smj.2017.40736

Abstract

INTRODUCTION & AIM OF THE WORK :
Depression and anxiety are common psychiatric comorbidities of epilepsy. This work aimed to assess the relationship between psychological disorders (depression and anxiety) and epilepsy and to explore the different factors involved in such relationship.

SUBJECTS AND METHODS:
We studied 100 patients with epilepsy in the neuropsychiatry department in Qena South Valley University Hospital for comorbid depression and anxiety. Hamilton questionnaire for depression and anxiety (HAMD and HAMA), EEG and brain Imaging were carried out..

RESULTS:
Demographic data of the studied population show that the mean ± SD of age is 25.08±13.81, male (64%), age of onset of epilepsy (19.18± 12.597), duration of treatment (4.82± 4.546). HAMD score (9.31±5.74), HAMA score (13.80±7.16). Depression was diagnosed in 48% and anxiety in 36% of patients. Among epileptic patients with depression or anxiety, no significant relation was detected regarding age, sex, educational level, age of onset nor duration of illness Depression was more in those with postictal drowsiness and GTC type of seizures.

Keywords

Depression and anxiety are common but underestimated epilepsy comorbidities

References

Kanner AM. Psychiatric issues in epilepsy: the complex relation of mood, anxiety disorders, and epilepsy. Epilepsy Behav. 2009;15:83–87.
Baker GA, Brooks J, Buck D, Jacoby A. The stigma of epilepsy: a European perspective. Epilepsia. 2000;41:98–104.
KannerAM,Palac S. Neuropsychiatric complications of epilepsy. CurrNeurolNeurosci Rep. 2002;2(4):365–72.
Lambert MV, Robertson MM. Depression in epilepsy: etiology, phenomenology, and treatment. Epilepsia. 1999;40:21–47. doi: 10.1111/j.1528-1157.1999.
D.C. Hesdorffer, W.A. Hauser, E. Olafsson, P. Ludvigsson, O. Kjartansson Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol, 59 (2006), pp. 35–41.
Hamiwka LD, Cara GY, Hamiwka LA, Sherman EM, Anderson B, Wirrell E. Are children with epilepsy at greater risk for bullying than their peers? Epilepsy Behav. 2009;15:500–505.
Sillanpää, M. and H. Cross, J (2009).“The psychological impact of epilepsy in childhood.” Epilepsy & Behavior 15: S5 - S10
Titlic M, Basic S, Lusic I. Co morbidity psychiatric disorders in epilepsy: a review of literature. Bratisl. LekListy 2009; 110 (2)
Barbara Błaszczyka. . StanisławJ.Czuczwar,.Epilepsy coexisting with depression. Pharmacological Reports. Volume 68, Issue 5, October 2016, Pages 1084-1092.
PanagiotisZisa, ParaskeviYfantia, AnnaSiatounib, AntoniosTavernarakisa, StylianosGatzonis. Determinants of depression among patients with epilepsy in Athens, Greece Epilepsy & Behavior. Volume 33, April 2014, Pages 106-109
Robert Dias, Lisa M.Bateman, Sarah Farias, Chin-ShangLi.TzuchunLin, Juliejorgensen, MasudSeyal. Depression in epilepsy is associated with lack of seizure control. Epilepsy & Behavior.Volume 19, Issue 3, November 2010, Pages 445-447
Miller JM1, Kustra RP, Vuong A, Hammer AE, Messenheimer JA. Depressive symptoms in epilepsy: prevalence, impact, aetiology, biological correlates and effect of treatment with antiepileptic drugs. Drugs. 2008;68(11):1493-509.
Taylor, RS, Sander, JW, Taylor, RJ, and Baker, GA. Predictors of health-related quality of life and costs in adults with epilepsy: a systematic review. Epilepsia. 2011; 52: 2168–2180
de Souza EA, Salgado PC. A psychosocial view of anxiety and depression in epilepsy. Epilepsy Behav. 2006;8:232–8. doi:10. 1016/j.yebeh.2005.10.011.
Haneef Z, Grant ML, Valencia I, Hobdell EF, Kothare SV, Legido A, Khurana D. (2010) Correlation between child and parental perceptions of health-related quality of life in epilepsy using the PedsQL V 4.0 measurement model. Epileptic Disord 12:275–282.
KimiskidisVasilios K , Nikolaos I Triantafyllou, EleniKararizou, StergiosStylianosGatzonis, Konstantinos N Fountoulakis, Anna Siatouni, PanagiotisLoucaidis, DimitraPseftogianni, NikolaosVlaikidis and George S Kaprinis. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables. Annals of General Psychiatry 2007, 6:28 doi:10.1186/1744-859X-6-28.