Role of autophagy in immune regulation

Hashim, Marwa; Mohamed, Nesma; Mahmoud, Ekram

doi:10.21608/smj.2018.36151

Role of autophagy in immune regulation

Document Type : Original Article

Authors

¹ Department of Biochemistry and microbiology, Facaulty of Medicine, Sohag University.

² Department of Biochemistry and microbiology, Faculty of Medicine, Sohag university.

³ Department of Biochemistry and microbiology, Faculty of Medicine, Sohag university

10.21608/smj.2018.36151

Abstract

Autophagy is a highly conserved protein degradation pathway responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone mediated
autophagy (CMA), and macroautophagy. Numerous studies reveal autophagy and autophagy related proteins also participate in immune regulation. in this review we summarized current understanding of the roles of autophagy and autophagy proteins in immune regulation.

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