Bacterial Biofilm in Chronic Suppurative Otitis Media

Document Type : Review Article


1 Microbiology,faculty of medicine ,sohag university, sohag

2 Department of Medical Microbiology and Immunology, Sohag Faculty of Medicine, Sohag University

3 Microbiology

4 Department of Otolaryngology,Faculty of medicine, Sohag university Sohag


One of the most prevalent inflammatory lesions in the specialty of otorhinolaryngology is chronic suppurative otitis media (CSOM). A chronic suppurative inflammatory reaction of the middle ear mucosa and tympanic membrane, known as chronic suppurative otitis media, frequently invades middle ear tissues such the tympanum, mastoid process, tympanic sinus, and eustachian tube. Tympanic membrane perforation, hearing loss, and intermittent or persistent pus discharge in the ear are the most prevalent clinical signs of this illness.

Microbes living in tightly clustered, slowly expanding microcolonies and encased in a matrix made of a protective biopolymer form biofilm. The microorganisms develop the highest degrees of immunity to antibiotics and the immune system in biofilms. The middle ear cavity's bacterial biofilm may serve as a reservoir for the bacteria that cause recurring or chronic ear discharge in patients with CSOM. The benefits of controlling this form of infection, its impacts and complications, and preventing the emergence of antibiotic resistance may result from the successful elimination of such bacterial behavior.


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