Role of leptin and visfatin in infertility in obese and non obese women

Document Type : Original Article

Authors

1 Faculty of medicine -sohag university

2 faculty of medicine -sohag university

3 faculty of medicine -sohag universty

Abstract

Infertility considered a big health problem with increasing prevalence, having several causes, some of these causes refer to adipose tissue abnormalities.
Many substances secreted from white adipose tissue like leptin ,visfatin may have a role in several cases in infertility in women
Objective:to answer questions concerned with the relation between lepin ,visfatin and omen's infertility  through analysis of data from previous studies.

Thwe strategy of this systematic review will be based on raising some research questions that give an idea about the relationship between leptin and visfatin level and women infertility.
لإhe research questions
1-Is there a relationship between obesity and infertility in women?
2-Is there a relationship between obesity and leptin and visfatin level ?
3- Is there a relationship between leptin and visfatin level and infertility in women  ?
4-Is there a difference in leptin ,visfatin level between obese and non obese infertile women ?
5-How does leptin ,visfatin affect women's fertility?

Keywords


 1. Boivin, J., Bunting, L., Collins, J. A., & Nygren, K. G. (2007). International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Human reproduction, 22(6), 1506-1512.

2.Saely, C. H., Geiger, K., & Drexel, H. (2012). Brown versus white adipose tissue: a mini-review. Gerontology, 58(1), 15-23.

3.Chan, J. L., Bullen, J., Stoyneva, V., DePaoli, A. M., Addy, C., & Mantzoros, C. S. (2005). Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess. The Journal of Clinical Endocrinology & Metabolism, 90(3), 1618-1624.

4-Wang, T., Zhang, X., Bheda, P., Revollo, J. R., Imai, S. I., & Wolberger, C. (2006). Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nature structural & molecular biology, 13(7), 661.

5- Polotsky, A. J., Hailpern, S. M.,
Skurnick, J. H., Lo, J. C., Sternfeld, B., & Santoro, N. (2010). Association of adolescent obesity and lifetime nulliparity—The Study of Women's Health Across the Nation (SWAN). Fertility and sterility, 93(6), 2004-2011.
6-Bellver, J., Pellicer, A., García-Velasco, J. A., Ballesteros, A., Remohí, J., & Meseguer, M. (2013). Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertility and sterility, 100(4), 1050-1058.
7- Sim, K. A., Dezarnaulds, G. M., Denyer, G. S., Skilton, M. R., & Caterson, I. D. (2014). Weight loss improves reproductive outcomes in obese women undergoing fertility treatment: a randomized controlled trial. Clinical obesity, 4(2), 61-68.‏
8- Kort, J. D., Winget, C., Kim, S. H., & Lathi, R. B. (2014). A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility. Fertility and sterility, 101(5), 1400-1403.
9- Esmaeilzadeh, S., Andarieh, M. G., Ghadimi, R., & Delavar, M. A. (2015). Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome. Global journal of health science, 7(2), 101.‏
10- McKinnon, C. J., Hatch, E. E., Rothman, K. J., Mikkelsen, E. M., Wesselink, A. K., Hahn, K. A., & Wise, L. A. (2016). Body mass index, physical activity and fecundability in a North American preconception cohort study. Fertility and sterility, 106(2), 451-459.‏
11-Zahorska-Markiewicz, B., Olszanecka-Glinianowicz, M., Janowska, J., Kocełak, P., Semik-Grabarczyk, E., Holecki, M., ... & Skorupa, A. (2007). Serum concentration of visfatin in obese women. Metabolism, 56(8), 1131-1134.‏
12- Samara, A., Pfister, M., Marie, B., & Visvikis‐Siest, S. (2008). Visfatin, low‐grade inflammation and body mass index (BMI). Clinical endocrinology, 69(4), 568-574.
13 Vardhana, P. A., Dicken, C., Tortoriello, D. V., Chu, M., Carmina, E., & Lobo, R.A. (2009). Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and visceral abdominal fat. International Journal of Gynecology & Obstetrics, 104(2), 121-124.‏
14- Kamińska, A., Kopczyńska, E., Bronisz, A., Żmudzińska, M., Bieliński, M., Borkowska, A., ... & Junik, R. (2010). An evaluation of visfatin levels in obese subjects. Endokrynologia Polska, 61(2), 169-173.‏
15- Reda, R., Shehab, A., Soliman, D., Gabr, A., & Abbass, A. (2011). Serum visfatin levels in a group of Egyptian obese individuals. The Egyptian journal of immunology, 18(1), 25-32.
16- Terra, X., Auguet, T., Quesada, I., Aguilar, C., Luna, A. M., Hernández, M., ... & Pellitero, S. (2012). Increased levels and adipose tissue expression of visfatin in morbidly obese women: the relationship with pro‐inflammatory cytokines. Clinical endocrinology, 77(5), 691-698.‏
17- Carmo Martins, M., Faleiro, L. L., & Fonseca, A. (2012). Relationship between leptin and body mass and metabolic syndrome in an adult population. Revista Portuguesa de Cardiologia (English Edition), 31(11), 711-719.‏‏
18- Derosa, G., Fogari, E., D’Angelo, A., Bianchi, L., Bonaventura, A., Romano, D., & Maffioli, P. (2013). Adipocytokine levels in obese and non-obese subjects: an observational study. Inflammation, 36(4), 914-920.‏

19- Bienertová-Vašků, J., Novák, J., Zlámal, F., Forejt, M., Havlenová, S., Jackowská, A., ... & Vašků, A. (2014). The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population. Eating behaviors, 15(2), 244-251.‏
20- Indulekha, K., Surendar, J., Anjana, R. M., Geetha, L., Gokulakrishnan, K., Pradeepa, R., & Mohan, V. (2015). Metabolic obesity, adipocytokines, and inflammatory markers in Asian Indians—CURES-124. Diabetes technology & therapeutics, 17(2), 134-141.‏
21- Luo, Q., Li, N., Abulikem, S., & Yao, X. (2016). 16-02 ASSOCIATION OF SERUM CONCENTRATIONS OF LEPTIN WITH OBESITY AMONG UYGUR POPULATION IN. Journal of hypertension, 34, e218.‏
22- Ersoy, C., Sadikoglu, G., Orhan, H., Guclu, M., Sarandol, E., Akgun, M. D., ... & Imamoglu, S. (2010). Body fat distribution has no effect on serum visfatin levels in healthy female subjects. Cytokine, 49(3), 275-278.‏
23- Miazgowski, T., Major-Goluch, A., & Safranow, K. (2012). Selected adipokines and metabolic profiles in normal-weight women with abdominal obesity. Pol Arch Med Wewn, 122(9), 406-412.‏
24- Saboori, S., Hosseinzadeh-Attar, M. J., Hosseini, M., Mirzaei, K., & Ahmadivand, Z. (2015). The comparison of serum vaspin and visfatin concentrations in obese and normal weight women. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 9(4), 320-323.‏
25- Demir, B., Guven, S., Guven, E. S. G., Atamer, Y., Gunalp, G. S., & Gul, T. (2007). Serum leptin level in women with unexplained infertility. Journal of reproductive immunology, 75(2), 145-149.‏

26- Shafi, R., & Afzal, M. N. (2008). Status of serum leptin levels in females with infertility. Saudi medical journal, 29(10), 1419-1422.‏
27- Farooq, R., Lutfullah, S., & Ahmed, M. (2014). Serum leptin levels in obese infertile men and women. Pakistan journal of pharmaceutical sciences, 27(1).‏
28-Kamyabi, Z., & Gholamalizade, T. (2015). A comparative study of serum and follicular fluid leptin concentrations among explained infertile, unexplained infertile and fertile women. International journal of fertility & sterility, 9(2), 150.‏
29- Nilgün Güdücü, Herman İşçi, Uzay Gِrmüş, Alin Başgül Yiğiter & Ilkkan Dünder. (2012 ).Serum visfatin levels in women with polycystic ovary syndrome. Gynecological Endocrinology, 28(8): 619–623.

30- Svendsen, P. F., Christiansen, M., Hedley, P. L., Nilas, L., Pedersen, S. B., & Madsbad, S. (2012). Adipose expression of adipocytokines in women with polycystic ovary syndrome. Fertility and sterility, 98(1), 235-241.‏

31- Farshchian, F., Tehrani, F. R., Amirrasouli, H., Pour, H. R., Hedayati, M., Kazerouni, F., & Soltani, A. (2014). Visfatin and resistin serum levels in normal-weight and obese women with polycystic ovary syndrome. International journal of endocrinology and metabolism, 12(3).‏

32- Gul, O. O., Cander, S., Gul, B., Açıkgoz, E., Sarandol, E., & Ersoy, C. (2015). Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome. European cytokine network, 26(4), 73-78.‏
33- Chou, S. H., Chamberland, J. P., Liu, X., Matarese, G., Gao, C., Stefanakis, R., ... & Mantzoros, C. S. (2011). Leptin is an effective treatment for hypothalamic amenorrhea. Proceedings of the National Academy of Sciences, 108(16), 6585-6590.‏
34-Zheng, S. H., Du, D. F., & Li, X. L. (2017). Leptin Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and a Meta-Analysis. Reproductive Sciences, 24(5), 656-670.‏

35- Tao, Y., Zhang, Q., Huang, W., Zhu, H., Zhang, D., & Luo, W. (2011). The Peritoneal Leptin, MCP‐1 and TNF‐α in the Pathogenesis of Endometriosis‐Associated Infertility. American Journal of Reproductive Immunology, 65(4), 403-406.‏

36- Barcz, E., Milewski, Ł., Radomski, D., Dziunycz, P., Kamiński, P., Roszkowski, P. I., & Malejczyk, J. (2008). A relationship between increased peritoneal leptin levels and infertility in endometriosis. Gynecological Endocrinology, 24(9), 526-530.‏

37- Choi, Y. S., Oh, H. K., & Choi, J. H. (2013). Expression of adiponectin, leptin, and their receptors in ovarian endometrioma. Fertility and sterility, 100(1), 135-141.‏
38- Dayer, D., Nikbakht, R., & Elyaderani, M. K. (2013). Comparison of leptin concentrations between infertile women with polycystic ovary syndrome and fertile women. Iranian journal of reproductive medicine, 11(12), 1033.‏
39-Jalilian, N., Haghnazari, L., & Rasolinia, S. (2016). Leptin and body mass index in polycystic ovary syndrome. Indian journal of endocrinology and metabolism, 20(3), 324.‏
40- Behboudi-Gandevani, S., Tehrani, F. R., Yarandi, R. B., Noroozzadeh, M., Hedayati, M., & Azizi, F. (2017). The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines. Journal of Endocrinological Investigation, 1-8.‏