Histiocyticneoplasia in the heart

Document Type : Original Article

Author

Department of pediatric ,Faculty of Medicine, Sohag university.

Abstract

Introduction: Histiocytic sarcomas are malignant proliferation of cell showing morphological and immunophenotypic characteristics of mature tissue histiocytes.
Objective : Is to report 3 years old girl presented with pyrexia of unknown origin and after echocardiography, MSCT on heart and MRI heart, the case was reported to have cardiac mass then after excisional biopsy of the mass and immunohistochemisrtry,histiocysticneoplasia was diagnosed.
Conclusion: Cardiac tumor should be excluded in the case of pyrexia of unknown origin.
 

  1. Uzun O, Wilson D G, Vujanic G M, Parsons J M, De Giovanni J V. Cardiac tumours in children. Orphanet J Rare Dis 2007;2:article 11. http://www.ojrd.com /content/2/1/11. Published March 1, 2007. Accessed September 9, 2012.
  2. Rappaport H. Histiocytosis. In: Atlas of tumour pathology: tumours of the haematopoietic system. Section 3, fascicle 8. Washington, DC: Armed Forces Institute of Pathology, 1966:48–63.
  3. McAllister HA Jr: Primary tumours of the heart and pericardium. PatholAnnu1979, 14:325-355.
  4. Holley DG, Martin GR, Brenner JI: Diagnosis and management of fetal cardiac tumors: a multicenterexperience and review of published reports. J Am CollCardiol1995, 26:516-52
  5. Lam KY, Dickens P, Chan AC: Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 1993, 117:1027-1031.
  6. Bulkley BH, Hutchins GM: Atrial myxomas: a fifty year review. Am Heart J 1979, 97:639-643.
  7. ChanHS, Sonley MJ, Moes CA, Daneman A, Smith CR, Martin DJ: Primary and secondary tumours of childhood involving the heart, pericardium, and great vessels. A report of 75 cases and review of the literature. Cancer 1985, 56:825-836
  8. Nadas AS, Ellison RC: Cardiac tumors in infancy. Am J Cardiol1968, 21:363-366.
  9. WarnkeRA, Weiss LM, Chan JKC, et al. Atlas of tumour pathology: tumours of the lymph nodes and spleen,Series 3, fascicle 14. Washington, DC: Armed Forces Institute of Pathology, 1995.
  10. Sun W, Nordberg ML, Fowler MR.Histiocytic sarcoma involving the central Mathe G, Gerard-Marchant R, Texier JL, et al. The two varieties of lymphoid tissue: ‘reticulosarcomas’, histiocytic and histioblastic types. Br J Cancer 1970;24:687–95.nervous system. Am J SurgPathol 2003;27:258–65.
  11. R. B. Scott and A. H. T. Robb-Smith, “Histiocyticmodullaryreticulosis,” The Lancet, vol. 2, pp. 194–198, 1939
  12. J. L. Hornick, E. S. Jaffe, and C. D. M. Fletcher, “Extranodalhistiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy,” The American Journal of SurgicalPathology, vol. 28, no. 9, pp. 1133–1144, 2004.
  13. T. M. Grogan, S. A. Pileri, J. K. C. Chan et al., “Histiocytic sarcoma,” in WHO Classification of Tumors of Haematopoieticand Lymphoid Tissues, S. H. Swerdlow, E. Campo, N. L. Harris et al., Eds., IARC, Lyon, France, 4th edition, 2008
  14. P. V. Aguiar,C.Dias, P. Azevedo et al., “Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient,” Journalof Nephropathology, vol. 4, no. 3, pp. 97–100, 2015.
  15. P. Kramer, M. E. F. Prins, J. G.Kapsenberg et al., “Persistent Epstein-Barr virus infection and a histiocytic sarcoma in a renal transplant recipient,” Cancer, vol. 55, no. 3, pp. 503–509, 1985.
  16. S. A. Pileri, T.M.Grogan, N. L. Harris et al., “Tumours  of  histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases,” Histopathology, vol. 41, no. 1, pp. 1–29, 2002.
  17. Copie-Bergman C, Wotherspoon AC,Norton AJ, et al. True histiocytic lymphoma: a morphologic, immunohistochemical and molecular genetic study of 13 cases. Am J SurgPathol 1998; 22:1386–92.
  18. Pileri SA, Grogan TM, Harris NL, et al.Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002;41:1–29.
  19. J. L. Hornick, E. S. Jaffe, and C. D. M. Fletcher, “Extranodalhistiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy,” The American Journal of SurgicalPathology, vol. 28, no. 9, pp. 1133–1144, 2004.
  20. E. Takahashi and S. Nakamura, “Histiocyticsarcoma : an updated literature review based on the 2008 WHO classification,” Journal of Clinical and Experimental Hematopathology, vol. 53, no. 1, pp. 1–8, 2013.
  21. S. A. Pileri, T.M.Grogan, N. L. Harris et al., “Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases,” Histopathology, vol. 41, no. 1, pp. 1–29, 2002
  22. S. K. Lau, P. G. Chu, and L. M. Weiss, “CD163: a specific marker of macrophages in paraffin-embedded tissue samples,” American Journal of Clinical Pathology, vol. 122, no. 5, pp. 794– 801, 2004.
  23. S. Boubenider, C. Hiesse, C. Goupy, F. Kriaa, S. Marchand, and B. Charpentier, “Incidence and consequences of post-transplantation lymphoproliferative disorders,” Journal ofNephrology, vol. 10, no. 3, pp. 136–145, 1997