Hypervirulent klebseilla pneumoniae (hvKp) is a new threat

Document Type : Review Article

Authors

1 medical microbiology and immunology

2 Department of Medical Microbiology and Immunology, Sohag Faculty of Medicine, Sohag University

3 Medical Microbiology and Immunology, Faculty of Medicine, Sohag University, Egypt

Abstract

Hypervirulent K. pneumoniae (hvKp) is a pathogenic strain of K. pneumoniae that is more virulent than classical K. pneumoniae (cKp). hvKp typically infects people in the community who are otherwise healthy. Infections are more common in the Asian Pacific Rim, but they occur worldwide. hvKp infection frequently manifests at various places or metastatically spreads, necessitating source control. hvKp has a greater proclivity to produce central nervous system infection and endophthalmitis, both of which necessitate prompt diagnosis and site-specific treatment.

K. pneumoniae has become a growing global problem in recent decades, owing to its increased resistance and lately concentrated hypervirulence. Despite the fact that SH 1V-1 -lactamase is encoded on the chromosome and is inherent resistance, K. pneumoniae can counteract antimicrobials by a variety of mechanisms, including hydrolyzing enzymes, missing porins, efflux overexpression, topoisomerase, and lipopolysaccharide (LPS) modification (4). Carbapenem-resistant K. pneumoniae (CR-KP) has reached an alarming rate of more than 30.0% among K. pneumoniae strains, posing serious hurdles in clinical practice. The World Health Organization (WHO) published a list of the most "critical" bacteria with an urgent need for novel therapies in 2016, with carbapenem-resistant Enterobacteriaceae (CRE) being designated as a critical priority organism

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Sohag Medical Journal
Volume 27, Issue 3. - Serial Number 3
Basic Science Volume
2023
Pages 21-26

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