Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.

Document Type : Review Article

Authors

1 Clinical and chemical pathology, Faculty of Medicine, Sohag University

2 Department:Clinical and chemical pathology, Faculty of Medicine, Sohag university

3 Department: Clinical and chemical pathology, Faculty of Medicine , Sohag university

4 Department: Clinical and chemical pathology, Faculty of Medicine, Assuit University

Abstract

Abstract:

TNF superfamily member (TRAIL) is a type II transmembrane protein and is responsible for initiating apoptosis. Macrophages, natural killer (NK), dendritic cells (DCs) and T cells all have TRAIL on their outer surfaces. Like other cytokines, the mature released protein lacks the signal sequence that is present in its pro-form. TRAIL can either be secreted as a dissolved protein or hydrophobic amino acids can attach it to the membrane. Both kinds can act as trimesters and initiate cell death. TRAIL promotes cell death by attaching to and activating trimeric death receptor. TRAIL is able to connect to five different receptors

Keywords: Secretion and exoression, Function of TRAIL, Mechanism of TRAIL Signaling Pathway, DISC, FADD, TRAIL Signaling Inhibition and TRAIL protect against diabetes.

Abbreviations: TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand, NK: Natural killer, DC: dendritic cells, IFN: interferon, DISC: death inducing signaling complex, FADD : Fas associated death domain .

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Sohag Medical Journal
Volume 27, Issue 3 - Serial Number 3
Clinical Science Volume
2023
Pages 53-56

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