The tumor site of origin and its effect on survival in gastrointestinal stromal tumors(GIST)

Document Type : Original Article

Authors

1 oncology department faculty of medicine Sohag university

2 Department of Clincal Oncology and Nuclear Medicine, Faculty of Medicine, Sohag University.

3 Department of Clinical oncology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Abstract

Abstract
Background: GIST is a common mesenchymal tumor of the Gastrointestinal Tract. The stomach is the most frequently affected site. In this study, we focus on the relation between tumor site and survival.
Materials and methods: our retrospective study included 47 patients diagnosed with GIST at Sohag University Hospital, Sohag Cancer Center, and Sohag Health Insurance Hospitals during the period between 2012 -2017. The collected data were extracted from patient's files. Missed data in the files were obtained via phone communication with the patients or their relatives.
Results: 47 cases with gastrointestinal tumors were selected. All tumors were stained positive for c-kit. 48.9% (23/47) of the tumors were located in the stomach, 40.4% (19/47) in the small intestine, and 10.6% (5/47) in the large intestine. The mean progression-free survival (PFS) was 20.75 months ranging between 7months and 39 months. On analyzing the impact of tumor site on PFS we found that There was a significant relationship between the gastric site of the tumor and improved PFS (log-rank P = 0.010). The mean overall survival (OS) was 35.26 months ranging between 1 month and 108 months, on analyzing the impact of tumor site on OS we found no relation.
Conclusion: Gastric origin of GIST is associated with more benign behavior and improved PFS in comparison with the intestinal origin.
Keywords: GIST, gastric GIST, survival.

Keywords

Main Subjects

Files

Share

How to cite

Statistics