Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Cognitive outcome of traumatic brain injury in elderly patients
11
13
EN
Momen
Mohamed
Almamoun
Department of Neurosurgery , Faculty of Medicine, Sohag University.
momenmohamed@med.sohag.edu.eg
Magda
Mohamed
Ali
Department of public health and community medicine, Faculty of Medicine, Sohag University.
magda_ali@med.sohag.edu.eg
Ahmed
Mohamed
EL Sayed
Department of Neurosurgery , Faculty of Medicine, Sohag University.
Roshdy
Abd Elaziz
Elkhayat
Department of Neurosurgery , Faculty of Medicine, Assuit University.
10.21608/smj.2018.34180
<strong>Objective</strong>: To assess the cognitive outcome of traumatic brain injury in elderly patients.<br /> <strong>Design:</strong> a prospective study.<br /> <strong>Methods</strong>this study was conducted on 50 elderly patients exposed to TBI in sohag university hospital and 50 patients exposed to TBI but less than 65 years used as a control.<br /> <strong>Introduction</strong>Traumatic brain injury (TBI) is a significant problem in older adults,and is associated with changes in the brain that affect the cognition<strong><em>(Sapoznik et al 2006) </em></strong><br /> <strong>Results</strong>During the study period, 50 elderly patients with TBI were followed up for cognitive outcome, 12 patients (24%) were associated with cognitive deficits.<br /> <strong>Conclusion:</strong> TBI in elderly patients is associated with cognitive deficits post injury
Traumatic brain injury,elderly patients,cognitive outcome,geriatric trauma,prognosis
https://smj.journals.ekb.eg/article_34180.html
https://smj.journals.ekb.eg/article_34180_098e5b4b5fe65a6499ab1d2b135998d6.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
METABOLIC SYNDROME INPATIENTS WITH RHEUMATOID ARTHRITIS
15
26
EN
Hanan
Sayed
Mohammed Abo-Zeid
Department of Rheumatology, Rehabilitation and Physical medicine - Faculty of Medicine- Sohag University.
hanan_abozaid@med.sohag.edu.eg
Ebtesam
Khalaf
Ali Fayez
Department of Rheumatology, Rehabilitation and Physical medicine - Faculty of Medicine- Sohag University.
ebtsamkhalaf@med.sohag.edu.eg
Ali
Mahmoud
Kasem
Department of Internal Medicine- Faculty of Medicine- Sohag University
Esam
Mohammed
Abo Al-Fadl
Department of Rheumatology, Rehabilitation and Physical medicine - Faculty of Medicine- Sohag University.
essam_mohamed@med.sohag.edu.eg
10.21608/smj.2018.34303
<strong>Objectives:</strong>To determine the prevalence of metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) and to evaluate the relation between parameters of MetS and clinical aspects of RA.<br /> <strong>Design: </strong>Cross-sectional study.<br /> <strong>Patients:</strong>Patients with rheumatoid arthritis (RA) according to 2010 ACR/EULAR classification criteria for RA (n = 150).<br /> <strong>Methods: </strong>Demographic data, arthritis history, medical and therapeutic history were evaluated. Height, weight, BMI, waist circumference (WC) and blood pressure (BP) were recorded. Disease activity was evaluated using DAS28 (ESR). Immunological investigations included RF, ESR, CRP, and anti-CCP. Fasting blood glucose and lipid profile were measured.The patient was diagnosed as having MetS according to 3 definitions; ATPIII (2004), IDF (2005), and JIS (2009).<br /> <strong>Results:</strong>Prevalence of MetS in rheumatoid patients was 48% (ATPIII definition), 52 % (IDF definition), and 46 % (JIS definition with Egyptian cut-off of WC), respectively. The most prevalent component of MetS was central obesity (75.3- 92 % according to the used definition).DAS28 was significantly higher in patients with MetS with higher number of tender joints and VAS (0-100) and most rheumatoid patients with MetS (68 %) had high disease activity.<br /> <strong>Conclusions:</strong>The increased prevalence of MetS components in RA patients, suggests greater attention be given to modifiable risk factors, including improvement of dietary habits, physical activity and blood pressure control.
Rheumatoid Arthritis,Metabolic syndrome,DAS28
https://smj.journals.ekb.eg/article_34303.html
https://smj.journals.ekb.eg/article_34303_d944f5a7466f79980580bfa5e68b4ef3.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Relation Between SF-36, mHAQ Scores and Disease Activity in Rheumatoid Arthritis
27
29
EN
Aya
Gmal
Specialist of Rheumatology and Rehabilitation Faculty of Medicine .Assiut University
Nagwa
Sayed
Ahmad
Debartment of Biochemistry, Faculty of Medicine, Sohag University.
nagwa_ahmed@med.sohag.edu.eg
Mohammed
AI
Debartment of Rheumatology and Rehabilitation Faculty of Medicine Sohag.
Nihal
A
F
Debartment Rheumatology and Rehabilitation Faculty of Medicine .Assiut University.
10.21608/smj.2018.34316
<strong>Objective: </strong>To investigate the relationship between quality of life (QOL) and disease activity in patients with rheumatoid arthritis (RA).<br /> <strong> </strong><br /> <strong>Methods: </strong>200 patients with RA were included in the study. Data were obtained by questionnaires and laboratory investigation. Disease Activity Score (DAS-28) was calculated for assessment of disease activity. Separate dimensions and physical and mental summary scores of the Short form Health survey (SF-36) and <em>Health Assessment Questionnaire</em> (HAQ) were compared to study the relationship between QOL and disease activity in patients with rheumatoid arthritis.<br /> <strong>Results: </strong>There was a significant association between DAS-28 and QOL scores.<br /> <strong>Conclusions: </strong>RA has a significant effect on the health related quality of life of patients, and its activity is ditectly related to worse QOL.
Rheumatoid Arthritis,quality of life,DAS-28,SF-36
https://smj.journals.ekb.eg/article_34316.html
https://smj.journals.ekb.eg/article_34316_9635f867d1a2b276ca954d7462e85c14.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Word Finding Difficulty Test Design and Standardization
31
41
EN
10.21608/smj.2018.34658
<strong>OBJECTIVE</strong>: The aim of this study is to design a new test for assessment of word finding difficulty in children in order to better assess and manage this problem. <br /> <strong>SUBJECTS AND METHODS</strong>: The test was designed and included pictures of different semantic groups. It was revised by Phoniatric experts. Then it was applied on a group of 50 normal children and a group of 25 DLD children with age range of 5-10 years with average or below average IQ. . <strong>RESULTS:</strong> The test consists of 7 sections. Validity of the test was examined by content validity, contrasted group validity and internal consistency validity. The results showed significant difference between scores of normal children and DLD children in all sections of the test. . <strong>CONCLUSION:</strong> Word finding difficulty test is suitable and easy applicable to assess word finding difficulty in children. It will help in accurate assessment of these children and therefore putting suitable plan for
https://smj.journals.ekb.eg/article_34658.html
https://smj.journals.ekb.eg/article_34658_c6a36a03f8a5e453d360a1f72657918e.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Virtual CT Colonography: Technique and findings: Single Institute experience.
45
52
EN
Hossam
saro
hossam.salah@med.sohag.edu.eg
khaled
Fawzy
Alkhayat
Department of Chest Diseases, Faculty of Medicine, Sohag University
khaled_mohamed@med.sohag.edu.eg
Mohammed
Al Sayed
alaa_abusedera@med.sohag.edu.eg
Mohammed
Zaki
Ali
10.21608/smj.2018.34677
Colorectal cancer is the second leading cause of death due to malignancy in industrialized counties. It is argued that most large bowel malignancies arise from preexisting adenormas. Computed tomographic (CT) colonography is a noninvasive, rapidly evolving technique that has been shown in some studies to be comparable with conventional colonoscopy for the screening of colorectal cancer. However, widespread colorectal screening and preventive efforts aimed at detecting disease in this early stage are opposed by several practical obstacles, including limited resources, and poor patient acceptance and therefore poor compliance (1-2).<br /> Patients and methods
https://smj.journals.ekb.eg/article_34677.html
https://smj.journals.ekb.eg/article_34677_aaf935fbbdfbfc5d6ec38ea248a8bb24.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Virtual CT Colonography Versus Lower Endoscopy in Detection of Colorectal Lesions.
53
64
EN
Hossam
saro
Faculty of Medicine- Sohag University.
hossam.salah@med.sohag.edu.eg
khaled
Fawzy
Alkhayat
Department of Chest Diseases, Faculty of Medicine, Sohag University
khaled_mohamed@med.sohag.edu.eg
Mohammed
Alaa
Al Sayed
Faculty of Medicine- Sohag University
alaa_abusedera@med.sohag.edu.eg
Mohammed
Zaki
Ali
Faclty of medicine-sohag university
Wael
Barakat
faculty of medicine- sohag university
10.21608/smj.2018.34967
Colorectal cancer is the third most common cancer and the second leading cause of cancer-related death in Western countries. As with other malignancies, screening and early detection is fundamental for successful management of colorectal cancer. Computed tomographic (CT) colonography is a noninvasive, rapidly evolving technique that has been shown in some studies to be comparable with conventional colonoscopy for the screening of colorectal cancer. CT colonography is being increasingly applied as a routine screening method for the detection of colorectal cancer in last few years as it is more convenient and less invasive than colonoscopy. In addition, it has an upper hand in diagnosis of small lesions less than 10mm <strong>(</strong><strong>Choi, et al.</strong><strong>, 2011).</strong><br /> <strong>Patients and methods:</strong>This prospective double blind comparative study will be conducted on 23 patients with colorectal symptoms and signs as altered bowel habits, bleeding per rectum, abdominal pain, weight loss, unexplained fatigue and loss of appetite.An informed written consent was obtained from all patients and approval of the faculty research ethics committee was obtained.<br /> <strong>Results: </strong>Total of 108 colonic lesions were analyzed in 23 patient; Seven colonic masses were diagnosed in 6 patients, 41 polyps in 8 patients and 60 diverticulae in 5 patients.<br /> Six patients had incomplete colonoscopy. Of them, 2 patients had a large polypoidal mass that prevents further colonoscopic introduction. Using CT colonography we were able to evaluate those polypoidal masses. Moreover, we could complete the examination and evaluation of the proximal colon and one of them had a polypoidal sigmoid colon mass and showed another proximal annular mass.<br /> Four patients presented with colonic obstruction and good preparation to the proximal parts of the colon failed, So completing the colonoscopy was difficult. After undergoing CT colonography, 2 patients were normal and 2 patients had annular masses causing proximal obstruction and marked distension.<br /> <strong>Conclusion</strong>CT Colonography (Virtual Colonoscopy) is a reliable tool and more sensitive for detecting colonic mass lesions larger than 5 mm, polyps larger than 5 mm, strictures and diverticulosis. CTC is of value in evaluating the colonic segment lying proximal to colonic cancers including those with occlusive growths or strictures. Contrast-enhanced CTC is also useful in identifying extra-colonic findings.Virtual Colonoscopy is a good screening tools for malignant or premalignant lesions in patients presented with colorectal symptoms.
https://smj.journals.ekb.eg/article_34967.html
https://smj.journals.ekb.eg/article_34967_8d91495b905d0bb331818e509e1daddd.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Role of leptin and visfatin in infertility in obese and non obese women
65
71
EN
Hussein
Hussein
Faculty of medicine -sohag university
Mahmoud
Abdel Fadeil
faculty of medicine -sohag university
Abdou Saeed
Ait-allah
faculty of medicine -sohag universty
10.21608/smj.2018.34992
Infertility considered a big health problem with increasing prevalence, having several causes, some of these causes refer to adipose tissue abnormalities.<br /> Many substances secreted from white adipose tissue like leptin ,visfatin may have a role in several cases in infertility in women<br /> <strong>Objective:</strong>to answer questions concerned with the relation between lepin ,visfatin and omen's infertility through analysis of data from previous studies.<br /> <br /> <strong>Th</strong>w<strong>e strategy</strong> of this systematic review will be based on raising some research questions that give an idea about the relationship between leptin and visfatin level and women infertility.<br /> لإhe research questions<br /> 1-Is there a relationship between obesity and infertility in women?<br /> 2-Is there a relationship between obesity and leptin and visfatin level ? <br /> 3- Is there a relationship between leptin and visfatin level and infertility in women ?<br /> 4-Is there a difference in leptin ,visfatin level between obese and non obese infertile women ?<br /> 5-How does leptin ,visfatin affect women's fertility?
leptin,Visfatin,Obesity,Infertility
https://smj.journals.ekb.eg/article_34992.html
https://smj.journals.ekb.eg/article_34992_02ad53dcd8adc2f0df3eee25f0c58c9d.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Updates of Pulmonary Embolism
73
80
EN
Mohamed
Elsayed
Department of Internal Medicine. faculty of medicine.sohag University
mohamed_elsayed@med.sohag.edu.eg
10.21608/smj.2018.35256
Pulmonary embolism (PE) is the third most common cause of cardiovascular death worldwide, behind myocardial infarction and stroke. Due to pulmonary bed obstruction, PE can result in acute right ventricular (RV) failure which is a life-threatening condition. Because most patients ultimately die within the first hours of presentation, early diagnosis is very important (1). Mortality due to pulmonary embolism varies greatly, depending on various factors including age, comorbid conditions, and stability on presentation. Patients with low-risk PE have a 1-year survival rate over 95%. In contrast, patients presenting with high risk PE and hemodynamic instability have an approximately 40% mortality rate within 90-days. In this review, we will discuss the basic pathophysiology of PE, risk factors for developing PE, and standard diagnostic testing modalities. We will also cover risk stratification of patients presenting with PE and the implications for treatment and disposition. While no exact epidemiological data are available, the incidence of PE is estimated to be approximately 60 to 70 per 100,000, and that of venous thrombosis approximately 124 per 100,000 of the general population (2). The European guidelines for the diagnosis and management of PE report annual incidence rates of venous thrombosis and PE of approximately 0.5 to 1.0 per 1000 inhabitants (3). However, the actual figures are likely to be substantially higher because silent PE can develop in up to 40% to 50% of patients with deep vein thrombosis (DVT) (3)
https://smj.journals.ekb.eg/article_35256.html
https://smj.journals.ekb.eg/article_35256_49ecfb347b337193925897adf5f53688.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
LIPID PROFILE INPATIENTS WITH RHEUMATOID ARTHRITIS: CORRELATION WITH DISEASE ACTIVITY
83
87
EN
Ali
Mahmoud
Kasem
Department of Internal Medicine- Faculty of Medicine- Sohag University
Esam
Mohammed
Abo Al-Fadl
Department of Rheumatology, Rehabilitation and Physical medicine,Faculty of Medicine- Sohag University.
essam_mohamed@med.sohag.edu.eg
Hanan
Sayed
Mohammed Abo-Zeid
Department of Rheumatology, Rehabilitation and Physical medicine - Faculty of Medicine- Sohag University.
hanan_abozaid@med.sohag.edu.eg
Ashraf
Ahmed
Abd El-Latif
Department of Dermatology, Venereology and Andrology- Faculty of Medicine- Sohag University.
ashraf_abdelwahab@med.sohag.edu.eg
Ebtesam
Khalaf
Ali Fayez
Department ofPhysical medicine,Rheumatology and Rehabilitation- Faculty of Medicine- Sohag University
ebtsamkhalaf@med.sohag.edu.eg
10.21608/smj.2018.35373
<strong>Objectives:</strong>To study changes in lipid profile in patients with rheumatoid arthritis (RA) and to evaluate the relation between lipid profile and disease severity of RA.<br /> <strong>Design: </strong>Cross-sectional study.<br /> <strong>Patients:</strong>Patients with rheumatoid arthritis (RA) according to 2010 ACR/EULAR classification criteria for RA (n = 150).<br /> <strong>Methods: </strong>Demographic data, arthritis history, medical and therapeutic history were evaluated. Disease activity was evaluated using DAS28 (ESR). Immunological investigations included RF, ESR, CRP, and anti-CCP.Lipid profile levels were measured.<br /> <strong>Results:</strong>Raised TG was found in 38 (25.3 %) of patients, raised TC was found in 69 (46 %) of patients and decreased HDL-C was detected in 85 (56.7 %) of the patients
Rheumatoid Arthritis,Lipid profile,DAS28
https://smj.journals.ekb.eg/article_35373.html
https://smj.journals.ekb.eg/article_35373_d13809ceb776516d2b2ec93de9d7fb62.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Radiological Parameters of Calcaneovalgus Deformity of the Foot
89
94
EN
Abodoma
Shabeb
Department of Orthopaedic and traumatoulogy , Faculty of Medicine, Sohag University.
Mohamed
Kenawy
Department of Orthopaedic and traumatoulogy , Faculty of Medicine, Sohag University.
Ahmed
Kassem
Department of Orthopaedic and traumatoulogy , Faculty of Medicine, Sohag University.
Ashraf
Marzouk
Department of Orthopaedic and traumatoulogy , Faculty of Medicine, Sohag University.
Hassan
Noamany
Department of Orthopaedic and traumatoulogy , Faculty of Medicine, Sohag University.
10.21608/smj.2018.36787
<strong>Background</strong> Calcaneo valgus deformity is postural deformity of infancy which is characterized by dramatic hyperdorsiflexion of the foot that appears to be plastered up against the anterior surface of the tibia. Planter flexion of the foot is frequently limited as a result of contracture of the anterior ankle and foot structures.<br /> <strong>Aim of the work:</strong>To asses radiological parameters of calcaenovalgus deformity of the foot in children.<br /> <strong>Patients and methods:</strong>The patients were children up to 5 years old. The participants were 7 males and 13 females. The affected foot were 10 right sided and 10 left sided.<br /> <strong>Results: </strong>The present study was designed to asses radiological parameters of calcaenovalgus deformity of the foot in children.<br /> <strong>Conclusion</strong> The radiological parameters of calcaenovalgus deformity of the foot in children varies widly accodrding it is vevtical talus or oblique talus deformity.
https://smj.journals.ekb.eg/article_36787.html
https://smj.journals.ekb.eg/article_36787_8fdfea6731eb2d3a8aaf117ed674c112.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Prognostic Factors Of Extradural Heamatoma Evacuation
95
103
EN
Ahmed
Ibrahem
ELsayed
Department of Neurosurgery , Faculty of Medicine, Sohag University.
Khaled
Nasser
Fadle
Department of Neurosurgery , Faculty of Medicine, Sohag University.
khaled_ahmed@med.sohag.edu.eg
Mohammed
Ahmed
AbdElaal
Department of Neurosurgery , Faculty of Medicine, Sohag University.
mohamed_abdelaal@med.sohag.edu.eg
Roshdy
Abd Elaziz
Elkhayat
Department of Neurosurgery , Faculty of Medicine, Assuit University.
10.21608/smj.2018.40569
<strong>Objective</strong>: To assess the<em> Prognostic Factors of Extradural Heamatoma Evacuation</em><br /> <strong>Methodology</strong> <strong>:</strong>This study was conducted on 50 patients with extradural heamatoma 14 females and 36males, the oldest was 63 years old and the youngest was 3 years old, with mean age of 38.48 years, the cause of trauma was road traffic accident in 23 patients of them and falling from high in 14 patients of them and assault in 11 patients and animal kick in 2 patients, according to the clinical presentation the most common was manifestation of increase intracranial tension as headache and vomiting in 38 cases, followed by Loss of consciousness in 28 patients and 19 cases have typical lucid interval followed by disturbed conscious level in 12 cases, then weakness of one sideof the body in 8 cases, then unilateral dilated pupil in 5 cases followed by fits in 2 cases, while 2 cases were neurologically free and one case has bilateral dilated fixed pupil,the volume of EDH was between 20-30cc in 27 patients and between30-40cc in 17 patients and between 40 -50cc in 5 patients and more than 50cc in one patient, the EDH located in temperoparietal region in 16 patients and purely in the temporal lobe in 13 patients and in the parietal lobe in 8 patients and frontoparietal in 6 patients and the frontal lobe in 3 patients and in the posterior fossa in 3 patients and biparietal in one patient ,we operate 2patients in the 1<sup>st</sup> hour and 14 in the 2<sup>nd</sup> and 14 in the 3<sup>rd</sup> and 10 in the 4<sup>th</sup> and 6 in the 5<sup>th</sup> and 4 cases after 5 hours.<br /> <strong>RESULT</strong>: We operate 50 patients 39 of them show full recovery and 7 patients show neurological deficit and 4 patients died and no one show vegetative state and from the 46 patients who recovered 6 patients develop superficial wound infection and one patients show recollection of EDH and reoperation.<br /> <strong>Conclusion</strong>: The EDH is more common in middle aged males .As regard the site of EDH we found that the site play minimal rule in the outcome of EDH and as the most common sites was temperoparietal and temporal so mostly the middle meningial artery is the most common source of EDH and the posterior fossa is the most dangerous site as one case of the 3 patient presented with posterior fossa EDH died (33.3%) followed by temporal lobe EDH as 2(6.5%) cases from the 15 case died. the size and time from the trauma to evacuation and clinical presentation of EDH thy are the major factors that affect EDH. The clinical presentation especially the conscious level is the main factor affecting theoutcome as all the 4 cases who died the GCS was less than 8 when they arrived.
Extradural Heamatoma,surgical evacuation,Prognostic factors
https://smj.journals.ekb.eg/article_40569.html
https://smj.journals.ekb.eg/article_40569_5355d961a2ede642663612b996ec0dca.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Sohag experience in treatment of Dorsolumbar fractures according to Thoracolumbar injury classification and severity score(TLICS)
105
109
EN
Ahmed
M.El-Dein
Abdelrhman
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
Ahmed
saleh
Shaker
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ahmed_saleem@med.sohag.edu.eg
Ahmed
Hamed
Kassem
Department of Orthopedic Surgery,Faculty of Medicine,Sohag University Hospital, Egypt.
ahmedhamed@med.sohag.edu.eg
Ashraf
Rashad
Ahmed
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ashraf_marzouk@med.sohag.edu.eg
Mohamed
El saed
Abdel-Wanis
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mohamed_abdelwanees@med.sohag.edu.eg
10.21608/smj.2018.40591
<strong>Background:</strong>.The Thoracolumbar Injury Classification and Severity Score (TLICS) was developed to improve injury classification and guide surgical decision making, yet validation remains necessary. This study evaluates the functional ,clinical and radiological outcome of patients with thoracolumbar spine trauma (TLST) treated according to the TLICS.<br /> <strong>Aim of the work:</strong>To validate the efficacy of Thoracolumbar injury classification and severity score (TLICS) in orthopaedic emergency department at sohag university hospitals.<br /> <strong>Patients and methods:</strong>The TLICS was prospectively applied to a consecutive series of patients (30 cases) treated for TLST between October 2016 and October 2017. Patients with a TLICS score more than 4 points were surgically treated, whereas patients with a TLICS score of less than 4 points were conservatively managed.Those with a score of equal 4 ,group were managed conservatively and the other were operated.The primary outcome was the American Spinal Injury Association Impairment Scale (AIS)<sup>(1)</sup>.<br /> <strong>Results:</strong>The decision taken according to TLICS either conservative if the final score 4. Conservative treatment in the form of rest and<br /> dorsolumbosacral brace .Operative in form of posterior fixation with or without decompression .Transpedicular fixation and decompression was needed in 10 cases (33.33%) because they were suffering from neurological insult.The mean age was 34years.There were a marked improvement in angle of kyphosis , vertebral height loss and Oswestry disability index .No patient had neurological worsening during the follow-up.<br /> <strong>Conclusion:</strong>.Thoracolumnar injury and severity score is valid and safe for management of thoracolumbar fractures and has good reliability.
https://smj.journals.ekb.eg/article_40591.html
https://smj.journals.ekb.eg/article_40591_03baba957681d134b76112dd944cc068.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Measurement of Knowledge, attitudes and practices of parents on misuse of antibiotics in children with acute upper respiratory tract infections in Sohag district
111
119
EN
eman
A.
mohamed
Department of public health and community medicine , Faculty of medicine, Sohag University, sohag, egypt.
eman_mohamed@med.sohag.edu.eg
ahmed
Fathy
Hamed
Department of public health and community medicine , Faculty of medicine, Sohag University, sohag, egypt.
ahmed_hamed@med.sohag.edu.eg
Fouad
M.
Yousef
Department of public health and community medicine , Faculty of medicine, Sohag University, sohag, egypt.
fouad_atya@med.sohag.edu.eg
Ayat
khalaf
Ahmed
Department of public health and community medicine , Faculty of medicine, Sohag University, sohag, egypt.
10.21608/smj.2018.40606
<strong>Background:</strong> Upper respiratory tract infections (URTIs) are considered to be the most common reason for children’s visits to outpatient clinics. The emergence and spread of resistance related to the irrational use of antibiotics is a major global public health problem.<br /> <strong>Aim of the work</strong>: This study aimed to assess parents’ knowledge, attitude, and practice (KAP) regarding the use of antibiotics in URTIs in children.<br /> <strong> Methodology</strong>: A cross-sectional study wascarried out among parents(N=800) of children who were attending the maternal and child health center in Sohag city and the family medicine unit in Elmahamdaelbahria village in the period from 1<sup>st</sup> July 2016 till 31<sup>th</sup> May 2017<br /> .<strong>Results:</strong>Our results revealed that females were about 62.6%, those not sharing in labor force were 55.9 %, and urban parents were about58.8%. The mean age of parents was 33 years old.There is a statistically highly significant difference between mother & father in mean scoresof knowledge, attitude, practice; they were lower in fathers. Also, there is statistically significant difference between parents with different ages in practice score. There are highly statistically significant differences between mothers who were sharing and not sharing in labor force in Attitude, Practice scores.<br /> <strong>Conclusion:</strong>Parents with loweducational level, rural residence, low income and with two children or less have lack of knowledge ,inappropriate beliefs andpractices so they are vulnerable for misusing antibiotics for their children.<strong> </strong>
https://smj.journals.ekb.eg/article_40606.html
https://smj.journals.ekb.eg/article_40606_7abd9f5ecbbf778d357a2fcdaa0d00a2.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Risk Factors of Delayed Milestones Among Children Attending Sohag General Hospital
121
136
EN
Ekram
M.
Abdel khalek
Department of Public Health and Community Medicine , Faculty of Medicine, Assiut university.
Sabra
M.
Ahmed
Department of Public Health and Community Medicine , Faculty of Medicine,Assiut university.
Ramadan
Abo El Hassan
Ahmed
Department of Pediatrics , Faculty of Medicine, Sohag university.
ramadan_mahmoud@med.sohag.edu.eg
Gamal
E.
Soliman
Department of Public Health and Community Medicine , Al-Azhar Faculty of Medicine, Assiut branch.
10.21608/smj.2018.40878
Developmental delay occurs when a child exhibits a significant delay in the acquisition of milestones or skills, in one or more domains of development (i.e., gross motor, fine motor, speech/language, cognitive, personal/social, or activities of daily living).<br /> <strong>Objectives:</strong> present study aims to investigate the most common risk factors of The delayed development in children under four years attending Sohag GeneralHospital.<br /> <strong>Subjects and methods: A </strong>case control study was conducted in Sohag General Hospital during the period from January 2015 to June 2016 on children attending Pediatric, Physiotherapy and phoniatric clinicsin Sohag General Hospital<em>, </em>Sohag Governorate. The sample size was 150 cases and 150 controls. One hundred and fifty children (aged 1.5 month to 48 months) diagnosed with developmental delay by a specialist or/and a developmental pediatrician were recruited as cases.<br /> <strong>Results: </strong>In the logistic regression model, the odds of developing delayed milestones is significantly higher among children with cyanosis (OR = 16.391), low birth weight (OR = 6.147), parental consanguinity (OR = 5.489), 1<sup>st</sup> birth order (OR = 4.048), urban residence (OR = 3.702) and history of neonatal jaundice (OR = 2.518).<br /> <strong>Conclusion:</strong> The urban children, first children and from few number of family members were more frequently at risk for developmental delay.
developmental delay,risk factors,Sohag General Hospital
https://smj.journals.ekb.eg/article_40878.html
https://smj.journals.ekb.eg/article_40878_26e0dd85a57250661798cbd4b2312544.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Fixation of pilon Fracture & Comminuted distal tibial fracture with Triangular External fixator
137
141
EN
Shazly
Saleh
Musa
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
shazli_mousa@med.sohag.edu.eg
Ahmed
I.
Eldosoky
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ahmed_eldesouky@med.sohag.edu.eg
Mostafa
I.
Ibrahim
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mostafaismail@med.sohag.edu.eg
Mohamed
A.
Ahmed
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mohamed_mohamed2@med.sohag.edu.eg
Hasan
M.
Ahmed
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
10.21608/smj.2018.40889
<strong>Back ground :</strong> patients with pilon fractures and distal comminuted fractures, These fractures give the surgeon a great challenge In methods of fixation starting from External fixator up to platting and Illizarov But our method of fixation which Is Triangular External fixator acheive a great success.
https://smj.journals.ekb.eg/article_40889.html
https://smj.journals.ekb.eg/article_40889_f6cbd89fc3e596906696d9e9e663b8ed.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
The Use of Interleukin-22 as a Novel Marker of Disease Activity in Female Patients with Rheumatoid Arthritis
143
153
EN
Laila
Mohamed
Yousef
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
lailamohamed@med.sohag.edu.eg
Sahar
Aboalftoh
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
sahr_mahran@med.sohag.edu.eg
Tamer
Mohamed
Abdel-Latef
Department of Clinical and Chemical pathology, Sohag Faculty of Medicine, Sohag University.
tamer_soliman@med.sohag.edu.eg
Khalid
Elsayed
Ali
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
10.21608/smj.2018.40904
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by progressively destructive joint inflammation and destruction of articular cartilage, bone and synovial hyperplasia. Cytokines play a fundamental role in the processes that cause inflammation, articular destruction and extra-articular manifestations associated with RA.The preferential production of interleukin22 (IL22) by T cells suggests that elevated levels of this cytokine exist in chronic, T cell-mediated diseases, such as psoriasis and RA and that IL-22 plays an important role in the pathogenesis of these disorders.<br /> <strong>Objective: </strong>To study the role of IL-22 in RA.<br /> <strong>Methods:</strong>IL-22 serum levelswere measuredin55 female patients with RA, 28 of them on medical treatment and the other 27 were newly diagnosed patients and in 18 healthy controls. Patients are assessed for clinical and laboratory variables. Correlations of IL-22 serum levels with disease activity markers as disease activity score for 28 joints (DAS28), serological markers, bone erosions were assessed.<br /> <strong>Results: </strong>IL-22 levels were increased in patients with RA compared with controls (mean 34.6 pg/ml and 3.2pg/ml, respectively; P < 0.001). Levels of IL-22 correlated positively with DAS28 score (P <0.001). C-reactive protein (CRP) correlated positivity with high levels of IL-22 in RA patients (mean 53.8 pg/ml; P < 0.001) and rheumatoid factor (RF) correlated positivity with high levels of IL-22 in RA patients (mean 46.1 pg/ml;P < 0.001). The presence of bone erosions was associated with high IL-22 levels (P = 0.008).<br /> <strong>Conclusion:</strong>IL-22 is elevated in the serum of patients with RA.Elevated serum IL-22allows discrimination between patients with different clinical and laboratory measures and indicates thepotential of IL-22 as an additional tool for assessment of activity in RA, particularly in patients with RFantibodies. IL-22 is associated with bone destructive disease.
Interleukin-22,Rheumatoid Arthritis,disease activity,Disease activity score 28
https://smj.journals.ekb.eg/article_40904.html
https://smj.journals.ekb.eg/article_40904_ea5fc0d13248fbc4ea9078a3fa85ecb5.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Efficacy of microneedling in treatment of acne scars
155
162
EN
ESSAMELDIN
ABDELAZIZ
NADA
0000-0003-0986-2486
Department of Dermatology , Venereology and Andrology, Faculty of Medicine , sohag university.
essameldin_nada@med.sohag.edu.eg
Ramadan
Saleh
Abdo
Department , of Dermatology, Venereology and Andrology , Faculty of Medicine- , Sohag University.
ramadan_saleh@med.sohag.edu.eg
Rasha
I.
Mohhmed
Department of Dermatology, Faculty of Medicine, Sohag University.
rashaismail@med.sohag.edu.eg
Mohammed
A.
Mostafa
Department of Dermatology, Faculty of Medicine, Sohag University.
10.21608/smj.2018.40927
<strong>Introduction</strong>: Microneedling is a relatively new minimally invasive procedure involving superficial and controlled puncturing of the skin by rolling with miniature fine needles.Traditionally used as a collagen induction therapy for skin rejuvenation and facial scars specially acne scars. <br /> <strong>Aim of the work: </strong>Evaluation of efficacy of microneedling in treatment of acne scars.<br /> <strong>Patients and Methods: </strong>Ten patients with post acne atrophic facial scars attending the outpatient clinic of Dermatology in Sohag University Hospitals between June2014 to September 2017 were offered six sessions of microneedling at an interval of 1 month.They were evaluated monthly and one month after completion of sessions for both efficacy and safety of the procedure.<br /> <strong>Results: </strong>The mean ± SD of the patients' age in the study population were26.900±5.952years old.eight females and two males with mean acne scars duration ± SD 8.500±6.311 years, 60% of patients had psychological distress from their acne scars. At the end of study duration Out of the ten patients 7(70%) achieved one grade reduction in their Goodman and Baron qualitative grading score while 4 patients (40% ) achieved reduction in their quantitative ECCA " Echella d'e valuation Clinique des cicatrices d'acne" score with 8.55% improvement in the ECCA score. The mean ECCA score value of V scar started to decrease earlier than U scar , but M scar was fixed up to end of sessions.<br /> 50% of patients had good satisfaction, 30% of them had very good satisfaction and only 10% had excellent satisfaction. All treated patients , had adverse events of temporary erythema, edema, bleeding, or a serous ooze resolving with crusting or scabbing following each session of microneedling but in 1 patient (10%) aggravation of acne occurred, bacterial infection not occurred in any of our patients. <strong> </strong><br /> <strong>Conclusion:</strong> Multiple minimally invasive sessions of skin microneedling is an effective treatment for post-acne atrophic scars with the advantage of being a relatively risk-free, in-office procedure with minimal patient recovery time.
Acne,scar,Microneedling
https://smj.journals.ekb.eg/article_40927.html
https://smj.journals.ekb.eg/article_40927_ee7186859ff97ffb497e2689da1bac36.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Efficacy of microneedling with topical vitamin C in treatment of acne scars
163
170
EN
ESSAMELDIN
ABDELAZIZ
NADA
0000-0003-0986-2486
DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university
essameldin_nada@med.sohag.edu.eg
Ramadan
Saleh
Abdo
Department , of Dermatology, Venereology and Andrology , Faculty of Medicine- , Sohag University
ramadan_saleh@med.sohag.edu.eg
Mohammed
A.
Mostafa
Department of Dermatology, Faculty of Medicine, Sohag University.
Rasha
I.
Mohhmed
Department of Dermatology, Faculty of Medicine, Sohag University.
rashaismail@med.sohag.edu.eg
10.21608/smj.2018.40958
<strong>Introduction</strong>: Acne scars are largely preventable complications of acne. 95% of the scars occur over the face thus impacting the quality of life. Correction of scars is the priority for acne patients. There is no single treatment modality that has been shown to be universally effective. Microneedling is a relatively new minimally invasive procedure used as a collagen induction therapy for skin rejuvenation and facial scars.<br /> <strong>Aim of the work: </strong>Evaluation of efficacy of microneedling with topical vitamin C in treatment of acne scars.<br /> <strong>Patients and Methods: </strong>Ten patients with post acne atrophic facial scars attending the outpatient clinic of Dermatology in Sohag University Hospitals between June 2014 to September 2017 were offered six microneedling sessions plus topical vit. C (during the session of microneedling and daily topical application in between sessions) microneedling sessions were four weeks apart. They were evaluated monthly and one month after completion of sessions for both efficacy and safety of the procedure.<br /> <strong>Results:</strong> The mean ± SD of the patients' age in the study population were 28.900 ±5.384yers old nine females and one males with mean acne scars duration ± SD 11.900±5.506 years, 90%% of patients had psychological distress from their acne scars. At the end of study duration Out of the ten patients 6(60%) achieved one grade reduction in their Goodman and Baron qualitative grading score and 2 (20%) achieved two grade reduction. According to the quantitative ECCA " Echella d'e valuation Clinique des cicatrices d'acne" score 80% 0f patients achieved reduction in their score with 27.5% improvement in the ECCA score. The mean ECCA score value of V scar started to decrease earlier than both U scar, and M scar. 40% of patients had excellent satisfaction and 60% had very good satisfaction. All treated patients, had adverse events of temporary erythema, edema, bleeding, or a serous ooze resolving with crusting or scabbing following each session of microneedling, bacterial infection not occurred in any of our patients. <br /> <strong>Conclusion:</strong> Multiple minimally invasive sessions of skin microneedling with topical vitamin C during sessions and daily application is an effective treatment for post-acne atrophic scars with the advantage of being a relatively risk-free, in-office procedure with minimal patient recovery time.
Microneedling,Vitamen C,acne scar
https://smj.journals.ekb.eg/article_40958.html
https://smj.journals.ekb.eg/article_40958_c9563750652df58d20d3cf739449999c.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Association of CA 15-3 and CEA with Clinicopathological Parameters In Patients With Metastatic Breast Cancer
173
178
EN
Zeinab
M
Mahmoud
Department of clinical and chemical pathology, Sohag Faculty of Medicine, Sohag University.
zainbdiab@med.sohag.edu.eg
Sahar
Aboalftoh
Abd Elwahed
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
sahr_mahran@med.sohag.edu.eg
Doaa
S.
El Badry
Department of Clinical Pathology, Faculty of medicine, Sohag university.
Ahmed
N.
Mohammed
Department of clinical pathology, Faculty of medicine, Sohag university.
ahmed_ahmed3@med.sohag.edu.eg
10.21608/smj.2017.40972
Background. Breast cancer is the most common cancer and the leading cause of cancer death for women<strong>, </strong>a third of women are diagnosed with breast cancer at a late stage when the disease has a poor prognosis. Serum tumor markers have been widely used as noninvasive tools for measuring treatment response, early diagnosis of recurrence and predicting prognosis. In breast cancer, the most widely used serum tumor markers are cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA). The aim of this study was to investigate the association of serum CA15-3 and CEA levels with clinicopathological parameters in patients diagnosed with metastatic breast cancer (MBC).<br /> Patients and methods. This retrospective study was conducted on 50 patients who had used to predict response to chemotherapy in patients with metastatic breast cancer. The concentration of serum CA15-3 and CEA levels were measured using chemiluminescent enzyme immunoassays (ABBOTT ARCHITECT). The upper limits of normal for CA15-3 and CEA were 31.3 U/ml and 5 ng/ml, respectively.<br /> Result. Of the 50 patients, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were identified in 37 (74%) and 32 (64%) patients, respectively. Elevated CA 15-3 and CEA levels were significantly associated with breast cancer molecular subtypes (P=0.005 and P=0.008, respectively). Elevated CA 15-3 level was correlated with bone metastasis (P=0.047).<br /> Conclusion. CA 15-3 and CEA level elevation at initial diagnosis of recurrence were found to be associated with breast cancer molecular subtype; these serum tumor markers are frequently increased in the HER2-enriched and triple negative (TN) molecular subtypes of breast cancer.
https://smj.journals.ekb.eg/article_40972.html
https://smj.journals.ekb.eg/article_40972_af30ed9a4047aea0926efd346abb54c6.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Comparative Prospective Study Between Platlete Rich Plasma and Steroid Injection in Treatment of Chronic Planter Fasciitis
181
186
EN
Wael
Adel
salama
Department of Orthopedics and Traumatology, Faculty of medicine, Sohag university, Egypt
waeladel@med.sohag.edu.eg
Mostafa
I.
Ibrahim
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mostafaismail@med.sohag.edu.eg
Abdel Rahman
Ali
Abo takia
Department of Orthopedics and Traumatology, Faculty of medicine, Sohag university, Egypt
Abdel Rahman
El sheikh
Department of Orthopedics and Traumatology, Faculty of medicine, Sohag university, Egypt.
10.21608/smj.2018.40981
<strong>Purpose:</strong>Compare the results of injection of steroid and PRP in cases of chronic plantar fasciitis
<strong>INTRODUCTION:</strong> plantar fasciitis can be a difficult condition to treat. results of platelet rich plasma (PRP) injection have been promising. We compared PRP to cortisone injection in the treatment of chronic plantar fasciitis resistant to conservative management.
<strong>METHODS:</strong>38 heels (20 heels in the steroid group and 18heels in the PRP group) with plantar fasciitis failed conservative treatment were included to receive either PRP or Steroid injection. All patients were assessed by Visual Analogue Score (VAS) for pain, at 2 weeks 1 month and 3months post injection .
<strong>RESULTS:</strong>Our study included 38 patients; 20 in the steroid arm and 18 had PRP injections. The average age of the steroid injection group was 43.1±9.7 years and in the PRP was 43.1±8.4 years (P= 0.698).
The starting average pain scores were 8.6 for both groups <br /> (P= 0.712). Then our patients were followed up clinically at 2 weeks, 1 month and 3 months following the injections. There was statistically significant lower VAS scores for the steroid injection group at all follow up visits (P< 0.001 in all follow ups). The average pain scores were 4.9 and 6.7 at 2 weeks follow up for the steroid injection versus the PRP respectively, it was 2 and 4.2 at 1 month and last 0.6 and 1.2 after 3 months respectively.
<strong>CONCLUSIONS:</strong><strong>Purpos</strong>The purpose of this study was to assess the safety and preliminary clinical results of platelet-rich plasma (PRP) injections for treating chronic plantar fasciitis<strong>Methods</strong>
Fourteen consecutive patients with chronic plantar fasciitis receiving three injections of PRP into the plantar fascia were assessed 12 months after the procedure. The modified Roles and Maudsley score and a visual analogue scale (VAS) for pain were used to evaluate the clinical results.
<strong>Results</strong>
According to criteria of the Roles and Maudsley score, at 12 months of follow-up, results were rated as excellent in nine (64.3 %), good in two (14.3 %), acceptable in two (14.3 %) and poor in one (7.1 %) patient. VAS for pain was significantly decreased from 7.1 ± 1.1 before treatment to 1.9 ± 1.5 at the last follow-up (<em>p</em> < 0.01).
<strong>Conclusions</strong>
In this single-centre, uncontrolled, prospective, preliminary study, results indicate that treating chronic plantar fasciitis with PRP injections is safe and has the potential to reduce pain.
This study demonstrates that both steroid and PRP injections are highly effective in treatment of chronic plantar fasciitis but improvement in pain was more rapid with steroid injection. This study recommends for follow up for a longer period than three months to compare long term benefits of steroids and PRP.
https://smj.journals.ekb.eg/article_40981.html
https://smj.journals.ekb.eg/article_40981_9510ae00e330c04990a4c523005d975b.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Assessment of Hemodialysis Adequacy in patients with Chronic Kidney Disease in the Hemodialysis Unit at Sohag University Hospital
187
191
EN
Lotfy
Hamed
Abo Dahab
Department of Internal Medicine, Faculty of Medicine, Sohag University.
loutfy_abodahab@med.sohag.edu.eg
Eman
Ahmed
Sabet
Department of Internal medicine ; Faculty of medicine; Sohag University.
eman_thabet@med.sohag.edu.eg
Emad
Ahmed
Mohammed
Department of Internal Medicine, Faculty of Medicine, Sohag University.
emad_youssif@med.sohag.edu.eg
Abdallah
abdel-Naiem
Department of Internal medicine ; Faculty of medicine; Sohag University.
10.21608/smj.2018.41088
<br /> <strong>introduction</strong><br /> evaluation of HD adequacy in patients with ESRD who were being maintained on regular HD in a trial to identify the prevalence and causes of inadequate HD among the patients and the impact of HD adequacy on other parameters<strong>.</strong><br /> <strong>design and setting</strong>:prospective study, at sohag university hospital in egypt.<br /> <strong>METHODS</strong> <strong> </strong><br /> All patients in this study were subjected to laboratory investigations including blood urea nitrogen (BUN) (before dialysis and after dialysis), serum albumin, and hemoglobin (Hb) level. <br /> <br /> • <strong>URR</strong> = (1 - [postdialysis BUN ÷ predialysis BUN])<br /> <br /> Kt/V was calculated using the second-generation Daugirdas formula <br /> <br /> • Single-pool <strong>Kt/V</strong> = −In (<em>R </em>−0.008 × <em>t</em>) + (4 −3.5 × <em>R</em>)×UF/<em>W</em>,<br /> <br /> <em>R </em>is the ratio of postdialysis to predialysis BUN; <em>t </em>is the length of a dialysis session in hours; UF is the ultrafiltration volume in liters; and <em>W </em>is the patient’s postdialysis weight in kilograms.<br /> <strong>RESULTS</strong><br /> The results shown that 69,64% of patients had adequate HD (KT\V >1,2),and only 30,36% of patients had indequate HD (KT\V>1,2). <br /> <strong>CONCLUSION</strong><br /> A significant percentage(69,64%) of patients in the HD unit of Sohag University hospital had adequate HD. HD adequacy was influenced by several factors such as duration and frequency of the dialysis session.
https://smj.journals.ekb.eg/article_41088.html
https://smj.journals.ekb.eg/article_41088_9147014111f5014f3ad1520416dad7d9.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
The Relationship of Serum 25-Hydroxyvitamin D Levels with Disease Activity in Upper Egyptian Patients with Rheumatoid Arthritis
192
198
EN
Abdullah
Ahmed
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Egypt.
abdalah_radwan@med.sohag.edu.eg
Ahmed
Allam
Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt.
ahmed_farag@med.sohag.edu.eg
10.21608/smj.2018.41100
<strong>Aim of the work:</strong> To assess the serum 25-hydroxyvitamin D concentrations [25(OH)D] and their relationship with parameters of disease activity in upper Egyptian patients with rheumatoid arthritis (RA).<br /> <strong>Patients and methods:</strong> A case-control study was made on 34 patients with RA and 34 healthy control subjects. The following values were assessed for each patient: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (Anti-CCP), visual analogue scale of pain (VAS), disease activity score 28 (DAS28), and serum 25-hydroxyvitamin D concentrations.<br /> <strong>Results:</strong> Patients with RA had mild to moderate (DAS28 ˂ 5.1) disease activity. The mean serum level of 25(OH)D in patients with RA (24.35±5.66 ng/ml) was significantly lower (<em>P</em>˂ 0.001) than controls (42.46±11.33 ng/ml). Serum 25(OH)D levels did not show correlation with disease duration, ESR, CRP, VASor DAS28 in patients with RA.Serum 25(OH)D levels were significantly correlated with age in RA patients (<em>P</em>˂ 0.01).Serum 25(OH)D levels had no relation to RF or anti-CCP positivity.<br /> <strong>Conclusion:</strong> Although serum 25(OH)D levels were lower in RA patients of upper Egypt, there was no correlation with disease activity parameters, therefore, serum 25(OH)D concentrations cannot be used to reflect disease activity.
disease activity,Rheumatoid Arthritis,Vitamin D
https://smj.journals.ekb.eg/article_41100.html
https://smj.journals.ekb.eg/article_41100_b999f141bfb8da4a345af3ed20484e7d.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Expansion in Head and Neck at Sohag University Hospital
199
206
EN
Gamal
Youssef
Elsayed
Department of Plastic Surgery Faculty of Medicine University of Sohag
gamal_elsayed@med.sohag.edu.eg
Esam
E.
Bahgat
Department of plastic surgery, Faculty of medicine, Sohag University.
Tarek
A
Abulezz
Department of plastic surgery, Faculty of medicine, Sohag University.
tabulezz@med.sohag.edu.eg
Hossam
F.
Abd El Hameed
Department of General surgery, Faculty of medicine, Sohag University.
hossam_abdelhameed@med.sohag.edu.eg
10.21608/smj.2018.41306
<strong>Background: </strong>Tissue expansion is widely used in the head and neck, it have many advantages as the expanded tissue have the same color and texture of the treated area of the skin.<br /> <strong>Objectives:</strong>The aim of this work is to evaluate the expander utilization in head and neck reconstruction regarding indications and complications.<strong>Patients and methods: </strong>This is a prospective study included 30patients (18 female and 12 male), their age ranged from 3 to 36 years with mean value of 16 years,all patients were evaluated and managed in the plastic surgery department at Sohag university hospital. <strong>Results: </strong>the most cases of tissue expander used for scalp reconstruction followed by neck and nose reconstruction, young aged mostly treated with tissue expander than old aged and female more than male. <strong>Conclusion:</strong>The use of expanders provides the surgeon with a very reliable, simple method of reconstruction, the most common indications of expander uses were the post burn lesion alopecia of the scalp, post burn scar of the face, congenital melanocytic nevus of the forehead, haemangioma of the nose and congenital lymphatic malformations of the neck. The most common complications were expander exposure, wound dehiscent and serosa.
tissue expander,Scalp,Reconstruction
https://smj.journals.ekb.eg/article_41306.html
https://smj.journals.ekb.eg/article_41306_70847c2841d3bd111fb449e3d5d971d5.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Use of mesenchymal stem cells in an experimental model of metabolic syndrome complicated with cardiomyopathy
207
211
EN
Nagwa
Ahmad
Department of Biochemistry, Faculty of Medicine, Sohag University.
nagwa_ahmed@med.sohag.edu.eg
Esam
Abdel Raheem
Department of Biochemistry, Faculty of Medicine, Sohag University.
essam_abdelmawgoud@med.sohag.edu.eg
Hanan
H.
Fouad
Department of Biochemistry, Faculty of Medicine, Cairo University.
Tahia
Saleem
Department of Biochemistry, Faculty of Medicine, Assuit University.
10.21608/smj.2018.41313
Obesity is a major global health issue. Most obese patients develop metabolic syndrome, a cluster of clinical features characterized by hypertension, insulin resistance and dyslipidemia this pre-diabetic condition has recognized as an independent risk factor for cardiovascular diseases, particularly hypertension, atherosclerosis and diabetic cardiomyopathy. MSC can differentiate into many mesenchymal cells as cardiomyocytes. The application of MSCs in the treatment of DC in recent years offers promising results. Stem cell therapy has emerged as a promising strategy for the treatment of dead myocardium, directly or indirectly, and seems to offer functional benefits to patients.Recently, a substantial number of clinical trials have proven that stem cell therapy is safe. Infusion of bone marrow-derived stem cells (BMCs) represents the greatest number of clinical studies for MI. This review highlights the use of mesenchymal stem cells in metabolic syndrome and diabetic cardiomyopathy
https://smj.journals.ekb.eg/article_41313.html
https://smj.journals.ekb.eg/article_41313_cebb07da3eb655ffea368190944dac04.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Comparing the Performance of Tissue Doppler versus Left Atrial Strain in Predicting Left Ventricular End Diastolic Pressure in Patients with Different Left Ventricular Ejection Fractions
213
221
EN
Aliaa
Mahfouz
Department of Cardiovascular Medicine, Aswan University, Aswan, Egypt.
Mohammed
Kamal
Salama
Department of Cardiovascular Medicine, Aswan University, Aswan, Egypt.
Ramadan
Ghalib
Mohamed
Department of Cardiovascular Medicine, Aswan University, Aswan, Egypt.
Mohamed
Ayman
Saleh
Department of Cardiovascular Medicine, Aswan University, Aswan, Egypt.
10.21608/smj.2018.41318
<strong>Background:</strong>Early trans-mitral inflow velocity and mitral annular tissue Doppler imaging (E/Em ratio) is widely applied to noninvasively estimate left ventricular (LV) filling pressures. However, E/Em ratio has a significant gray zone among patients with severely impaired ejection fraction. Speckle tracking echocardiography (STE) was recently proposed as an alternative surrogate to estimate LV filling pressures. This study aimed at assessing performance of tissue Doppler parameters and left atrial global longitudinal strain as non-invasive surrogates for LV filling pressures and comparing accuracy of these two parameters across different striae of LVEF.<br /> <strong>Methods</strong>: A total of 96 patients with sinus rhythm and different ejection fraction who divided into four groups of 24 patients each according to their EF(>55%, 45–54%, 30–44%, and <30%), had an invasive measurement of the LV pressure. Both medial and lateral E/Em ratio were measured in all subjects by 2D Tissue Doppler, peak atrial longitudinal strain (PALS) and Peak atrial contraction strain (PACS) were obtained by averaging all segments measured in the 4-chamber.<br /> <strong>Results: </strong>Significant Correlation between global PALS and invasive LVEDP in all groups (r = 0.70 P < 0.000), While Lateral E/E’ shows significant correlation only in two groups; preserved and mildly impaired EF (r=0.42 P=0.023, r=0.439 p-0.032; respectively)<br /> <strong>Conclusion:</strong>In patients with preserved or mildly reduced LV ejection fraction, global PALS and Lateral E/E’ ratio presented good correlations with LVEDP. In patients with moderate or severe reduction of EF, E/E’ ratio correlated poorly with invasively measured LV filling pressures. Global PALS provided an overall better estimation of LV filling pressures.
https://smj.journals.ekb.eg/article_41318.html
https://smj.journals.ekb.eg/article_41318_bd5d489f8bde850e7fe8c714b9510ede.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Closed Reduction and Percutaneous Screws Fixation in Tibial Plateau Fractures
223
227
EN
Omar
M
Abdelkareem
Department of orthopedics and traumatology, Sohag University, Egypt.
Anis
Alsaut
Shiha
Department of orthopedics and traumatology, Sohag University, Egypt.
anies_sheha@med.sohag.edu.eg
Hussam Eldin
M
Elazab
Department of orthopedics and traumatology, Sohag University, Egypt.
hossameldin_azab@med.sohag.edu.eg
Mohamed
Ali
Department of orthopedics and traumatology, Sohag University, Egypt.
10.21608/smj.2018.41657
<strong>Purpose:</strong>To evaluate treatment outcomes of closedreduction and percutaneous screw fixation for tibialplateau fractures.<br /> <strong>Methods:</strong>18 men and 4 women aged 21 to 64 (mean, 38.1) years underwent closed reduction and percutaneous screw fixation for closed tibial plateaufractures. According to theSchatzker classification, patients were classifiedinto type I (n=6), type III (n=10), type IV (n=4), andtype V (n=2). Closed reduction was achieved usingmanual ligamentotaxis with traction in extensionunder image intensifier control. Reduction was fixedpercutaneously with cancellous screws (6.5 mm) andwashers. Functional outcome (pain, walking capacity,extension lag, range of motion, stability and return to daily activity) wasevaluated using the Modified Hospital for Special Surgery Score. A total score of 55 to 60 was considered as excellent, 45 to 54 as good, 35 to 44 as fair, and <strong>Results:</strong>Patients were followed up for a mean of 8 (range, 6–12) months. The mean length of hospitalstay was 2 (range, 1–3) days. All the fracture unitedradiographically after a mean of 3 (range, 2.5–3.5)months. Respectively in Schatzker types-I, -III, -IV, and-V fractures, outcomes were excellent in 4, 1, 1, and 0 patients, good in 2, 6, 2, and 0 patients, fair in 0, 3, 0, and 1 patients, and poor in 0, 0, 1, and 1 patients.<br /> Outcome was satisfactory (good-to-excellent) in 100%, 70%, 75%, and 0% of the respective fracture typesof patients. The mean Modified-HSS score was 46.2 for all patients; it was 53.3 for type I, 40.3 for typeIII, 45 for type IV, and 36 for type V fractures. One patient had metal failure due to early weight bearing at 5 weeks. No patient had infection or wound dehiscence.<br /> <strong>Conclusion:</strong>Closed reduction and percutaneous screw fixation for tibial plateau fractures is minimally invasive. It reduces the length of hospitalstay and costs, enables early mobilization with minimal instrumentation, and achieves satisfactory outcomes.
https://smj.journals.ekb.eg/article_41657.html
https://smj.journals.ekb.eg/article_41657_8b3cdab8ef79d2cf47af2099e8f0bf2d.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Prevalence of gyrA and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different Fluoroquinolones
229
241
EN
Laila
M
Yousef
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
lailamohamed@med.sohag.edu.eg
Ghada
A
Ismael
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University.
Ashraf
k
Mohammed
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
ashraf_abdallah@med.sohag.edu.eg
Mohamed
H
Mahmoud
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
10.21608/smj.2018.41679
<strong>Introduction</strong>: Streptococcus pneumoniae is a major Gram-positive pathogen responsible for pneumonia, bactermia, otitis media, and meningitis leading to considerable morbidity and mortality among children and elderly individuals. The primary goals of antibiotic treatment of respiratory tract infections are clinical efficacy of treatment, pathogen eradication, and prevention of resistance development. Resistance to fluoroquinolones in S. pneumoniae arises in a stepwise fashion and results from alterations in the target binding site due to the acquisition of spontaneous mutations in the quinolone resistance-determining regions (QRDRs) of the topoisomerase IV and DNA gyrase genes. Although mutations usually occur in the QRDRs of parC and gyrA, a role for mutations in the parE subunit in low-level resistance has been reported.<br /> <strong>Aim of the work: </strong>The aim of this study was to determine the prevalence of fluoroquinolone resistance Streptococcus pneumoniae (FQRSP) and to examine the genetic relatedness of pneumococcal isolates with parE and gyrA genes mutations in different specimens in Sohag University Hospital.<br /> <strong>Patients and Methods: </strong>This study was prospectively conducted over a period of 24 months between October 2015 and September 2017, at Sohag university hospital. During the study period, 78 patients hospitalized for a syndrome consistent with a diagnosis of community acquired pneumonia (CAP ) included in this study with a mean age of 34.5 years (range, 2 to 67), 60% of whom were males. A CAP syndrome was defined as a newly recognized pulmonary infiltrate together with 2 of the following findings: subjective fever or documented temperature 37.4 °C, increased cough, sputum production, or shortness of breath, pleuritic chest pain, confusion, rales, leukocytosis, (according to age) <strong>(1)</strong>. Patients who had taken antibiotic treatment within 3 days prior to initial visit were excluded from this study.<br /> <strong>Results: </strong>Our study illustrate the role of mutation in the gyrA&parE genes and the effect of mutations in the both genes in fluoroquinolone resistance among S. pneumoniae isolates.<br /> <strong>Conclusion: </strong>The present study provide an opportunity to view the predominant mutations conferring reduced susceptibility to FQs in clinical pneumococcal isolates. There is a strong relationship between these mutations and decrese susceptibility to the most fameous FQs to some extent, although this varies between strains and for each drug.
gyrA,ParE,Streptococcus pneumonia,Fluoroquinolones
https://smj.journals.ekb.eg/article_41679.html
https://smj.journals.ekb.eg/article_41679_9e04a14890c2922fbe60fb891a0eca5d.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Comparative study between Tramadol and Midazolam as an admixture to bupivacaine inUltrasound guided supraclavicular brachial plexus block.
243
250
EN
Mostafa
M
Abdelzaher
Department of Anesthesiology, Sohag University, Egypt.
Hamza
Abo-Alam
Mahmoud
Department of Anesthesia, Faculty of Medicine,Sohag University.
hamza_aboalam@med.sohag.edu.eg
Ahmed
Mohammed
Abd El-Mabood
Department of Anesthesia, Faculty of Medicine,Sohag University.
ahmed_abdelmaboud@med.sohag.edu.eg
Khaled
Mohamed
Hassan
Department of Anesthesiology, Sohag University, Egypt.
khaled_hassan@med.sohag.edu.eg
10.21608/smj.2018.41680
<strong><em>Background:</em></strong>This is a prospective, randomized, double blind study to evaluate the postoperative analgesia following ultrasound guided supraclavicular brachial plexus block with Tramadol or Midazolam as an admixture to bupivacaine in upper extremity surgery.<br /> <strong><em>Patientsand methods:</em></strong>Total 60 patients of ASA I and II undergoing upper extremity surgery under ultrasound guided brachial plexus block with Bupivacaine were randomly divided in to two groups; one group received Tramadol (1mg/kg) and the other group received midazolam (0.05mg/kg) as an admixture to Bupivacaine. The duration of postoperative analgesia was recorded in both groups using pain VAS score.<br /> <strong><em>Results: </em></strong>The mean duration of postoperative analgesia in the Midazolam group was 650±47.49 minutes while in the tramadol group it was 508±30.44 minutes.<br /> <strong><em>Conclusion: </em></strong>We concluded that midazolamwith local anaesthetic prolongs postoperative analgesiasignificantly than Tramadol (P<0.0001) when used as admixture to local anaesthetic inUltrasound guided brachialplexus block in upper extremity surgery.
Analgesia,brachial plexus,Ultrasound,midazolam,tramadol
https://smj.journals.ekb.eg/article_41680.html
https://smj.journals.ekb.eg/article_41680_b089ee6a7dfd61843671a085c944b8a8.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Prevalence of Fluoroquinolone-Resistant Clinical Isolates of Escherichia Coli in Urinary Tract Infection
253
262
EN
Laila
Yousef
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
lailamohamed@med.sohag.edu.eg
Ashraf
k
Mohammed
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
ashraf_abdallah@med.sohag.edu.eg
Ahmed
M
Mohamed
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
ahmed_ibrahim@med.sohag.edu.eg
Doha
M
Ali
Department of Clinical and chemical pathology, Sohag Faculty of Medicine, Sohag University.
10.21608/smj.2018.41769
<strong>Introduction</strong>: The commonest bacterial agent involved in causation of UTIs is Escherichia coli. The emergence of FQ resistant uropathogenic E. coli is of great concern.<br /> <strong>Aim of the work: </strong>to study resistance towards urinary E. coli with various generations of fluoroquinolones.<br /> <strong>Patients & Methods</strong>:<strong>: </strong>our study was carried out in the Clinical Pathology Department, Sohag University Hospital during the period from June 2016 to May 2017. Our study included 140 participants. Isolates from the specimens were obtained and identified using; Gram staining, colony characteristics on different culture medias. VITEC 2 Compact 15 identification kits were be used to confirm the identification of the isolates<br /> <strong>Results: </strong>E.coli was isolated from 100 patients (71%) of all patients complaining of UTI with positive urinary culture (study or case group). By studying prevalence of Antibiotic resistance of E.coli isolates reveals that fluoroquinolones show sensitivities of 42-46%. Also Nitrofurantoin has the highest sensitivity of 87%. This is followed by meropenem (67%). Ampicillin shows sensitivity in only 6% of cases. Regarding drug sensitivity in out & inpatients, we find that all generations of fluoroquinolones show highly significant resistance ratios among inpatients compared to outpatients. Meropenem show resistance more in inpatients than outpatients, with significant difference, Ampicillin and Nitrofuratoin show non-significant difference.<br /> <strong>Conclusion:</strong> our study show an increased fluoroquinolone resistance among uropathogenic E. coli isolates mainly in hospital admitted patients.
Urinary tract infection (UTI),Escherichia coli and fluoroquinolone resistant E.coli
https://smj.journals.ekb.eg/article_41769.html
https://smj.journals.ekb.eg/article_41769_57d877911adb22fef942a56f2ac65404.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Comparison of Fixation of supracondylar humeral fractures in children by lateral cross-wiring technique versus traditional lateral pinning
265
271
EN
Abdelrahman
A
Sadek
Department of Orthopedic, Faculty of Medicine, Sohag University.
Mostafa
Elsayed
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mostafaismail@med.sohag.edu.eg
Hussam Eldin
M
Elazab
Department of orthopedics and traumatology, Sohag University, Egypt.
hossameldin_azab@med.sohag.edu.eg
Hassan
Hamdy
Abdel Rahman
Department of Orthopedic, Faculty of Medicine, Sohag University.
hassan_abdelrahman@med.sohag.edu.eg
10.21608/smj.2018.41770
Introduction The currently accepted treatment for displaced supracondylar humeral fractures in children is closed reduction and fixation with percutaneous Kirschner wires. The aim of this study was to study the results of a cross-wiring technique, achieved solely from the lateral side, in an effort to reduce the risk of ulnar nerve injury.<br /> <strong>Conclusion</strong> there was no significant difference between lateral cross-wiring technique and traditional lateral pinning as regard postoperative clinical results and radiological results.<br /> Introduction<br /> <br /> <br /> Supracondylar fractures of the humerus in children accounts for 60% of all fractures around the elbow. (1) It represents 4 - 6.5% of all paediatric fractures. In treatment of non-displaced Type I fractures simple immobilization with a posterior splint applied at 60-90<sup>o</sup> of elbow flexion is preferred. (2) Currently, the treatment of choice for type II fractures is operative reduction and pinning rather than cast. (3) Most cases of type III fractures require operative reduction and pinning. The results of type III fractures treated with closed reduction and cast immobilization are not as good as the results of pinning. (4) There are various options for the pattern of K-wire fixation of displaced supracondylar fractures. Studies found the greatest resistance to rotation occurred with medial-lateral cross pinning. (5) The second most stable pattern was fixation utilizing three lateral diverging pins. The least stable was fixation with two lateral pins, which cross at the fracture site. While medial-lateral cross pinning has the greatest resistance; the disadvantage is the risk of ulnar nerve injury. (6) Lateral pinning is recommended (7) to avoid iatrogenic ulnar nerve injury that can occur with medial lateral cross pinning. Although iatrogenic ulnar nerve injuries usually resolve, several permanent iatrogenic ulnar nerve injuries have been described. (8) Closed reduction and lateral cross-wiring technique with ascending and descending K-wires is an effective method to treat type II and III supracondylar fractures in children. Regardless of stability, this method can be used to avoid iatrogenic ulnar nerve injuries. (9)<br /> Aim of the work<br /> The aim of this work is to assess clinical results of fixation of supracondylar humeral fractures by lateral cross-pinning versus traditional lateral pinning in children.
https://smj.journals.ekb.eg/article_41770.html
https://smj.journals.ekb.eg/article_41770_b98ef9df22483eb1d2ca2e322a6ef06d.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Value of High Sensitive CRP in Hyperglycemic Patients with Acute Coronary Syndrome
273
280
EN
Alaa
Ez El-Deen
Said
Department of Internal Medicine, Sohag university Hospital.
Omar
Saad
Mohammed
Department Internal Medicine, Sohag university Hospital.
omar_salim@med.sohag.edu.eg
Yasser
Mohamed
Kamal
Department of Internal medicine , Faculty of Medicine, Sohag University.
yasser_kamal@med.sohag.edu.eg
Adel
Abdel Aziz
El Sayed
Department Internal Medicine , Sohag university Hospital.
adel_elsayed@med.sohag.edu.eg
10.21608/smj.2018.41790
<strong><em>BACKGROUND</em></strong><strong>:</strong> Hyperglycemia on admission in patients with acute coronary syndromes is common, and it is a powerful predicator of increased risk of in hospital complications in patients with and without diabetes mellitus, high sensitivity c- reactive protein (hs- CRP) is a cardiovascular risk marker in patients<br /> with acute coronary syndrome.<br /> <strong><em>OBJECTIVES</em></strong><strong>:</strong><br /> <strong>1</strong>. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome with admission hyperglycemia whatever diabetic or not.<br /> <strong>2</strong>. To determine the levels of high-sensitivity C-reactive protein (hs-CRP) in subjects of acute coronary syndrome without admission hyperglycemia.<br /> <strong>3</strong>. To compare the results of the above two groups and assess the prognostic value of admission glucose and hs -CRP levels in hyperglycemic patients with acute coronary syndromes.<br /> <br /> <strong><em>DESIGN AND SETTING</em></strong><strong>:</strong> Prospective study, at Sohag university hospital in Egypt.<br /> <strong> </strong><br /> <strong><em>METHODS</em></strong><strong>:</strong> We measured the blood glucose, hs -CRP, cardiac enzymes and HBAIC levels at admission in 100 consecutive patients with ACS. Glucose was categorized as ≤11.1mmol=200 mg/dl. hs -CRP negative 3 mg, HBAIC ≤ 6.5% or ≥ 6.5).<br /> <strong> </strong><br /> <strong><em>RESULTS</em></strong><strong>:</strong> In our study reveals a statistically significant relation between levels of admission glucose and left ventricular function (LV failure, pulmonary edema and cardiogenic shock) or arrhythmias in hyperglycemic patients with ACS (P< 0.0001).<br /> Also there is a significant relation between level of hs- CRP and LVF and type of myocardial infarction in-hospital complications. <br /> Also there is insignificant relation between HBAIC levels and left ventricular function in ACS at admission. <br /> <strong><em>CONCLUSION</em></strong><strong>:</strong> We conclude that elevated admission glucose appears a more important in predicting in-hospital and short term complications particularly left ventricular failure and cardiogenic shock in patients with acute coronary syndromes. Also the increased levels of hs- CRP are a predictor for severity and extent of myocardial damage and left ventricular function especially in STEMI.<br /> The synergistic effect of associated both stress hyperglycaemia and hs- CRP is a strong predictor for poor ACS outcome.
High-sensitivity C-reactive protein level,hyperglycemia,Inflammatory marker,Atherosclerosis,Acute Coronary Syndrome
https://smj.journals.ekb.eg/article_41790.html
https://smj.journals.ekb.eg/article_41790_531d1e8793f308dadec21157c5eb0775.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Ischemic Heart Disease in Patients with Diabetes Mellitus
281
290
EN
Alaa
Ahmed
Ghaleb
Department of Internal Medicine, Faculty of Medicine, Sohag University.
alaa_ahmed@med.sohag.edu.eg
Elham
Omar
Hamed
Department of Clinical andChemical pathology, Sohag Faculty of Medicine, Sohag University.
elhamomar@med.sohag.edu.eg
Ahmed
Mohamed
Boghdady
Department of Internal Medicine, Faculty of Medicine, Sohag University.
ahmed_boghdady@med.sohag.edu.eg
Hassan
Ahmed
Hassanin
Department of Internal Medicine, Faculty of Medicine, Sohag University.
hassan_hassanain@med.sohag.edu.eg
10.21608/smj.2018.41796
https://smj.journals.ekb.eg/article_41796.html
https://smj.journals.ekb.eg/article_41796_4eab2a2fedfff612ec9a39a381d12370.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Comparative study between posterior and modified posterior approaches of humeral diaphyseal fractures in adults
291
295
EN
Emad
Girgis
Nagib
Department of Orthopaedic and Traumatology , Faculty of Medicine , Sohag Univeristy.
Ahmed
saleh
Shaker
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ahmed_saleem@med.sohag.edu.eg
Wael
Adel
salama
Department of Orthopedics and Traumatology, Faculty of medicine, Sohag university, Egypt.
waeladel@med.sohag.edu.eg
Ahmed
I.
Eldosoky
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ahmed_eldesouky@med.sohag.edu.eg
Shazly
Saleh
Musa
Department of Orthopaedic and Traumatology , Faculty of Medicine , Sohag Univeristy.
shazli_mousa@med.sohag.edu.eg
10.21608/smj.2018.41805
<strong>Introduction</strong> The optimal treatment of humeral shaft fractures continues to be debated. In the current investigation, we sought to determine the clinical and radiographic outcomes following the plate fixation of humeral shaft fractures utilizing the modified posterior approach. <br /> <strong>Materials and methods </strong>A retrospective review identified a consecutive series of 30 humeral shaft fractures (OTA20-A, 10-B, or 0-C) treated with plate fixation via a posterior (14 patients), ormodified posterior approach (16 patients) between 2016 and 2017 by a single surgeon. Demographics, operative reports, clinical follow-up, and preoperative radiographs were reviewed. Postoperative radiographs were assessed for angular deformity and time to union. Range of motion and strength testing were also reviewed. Results A total of 30 humeral shaft fractures were reviewed with a mean clinical follow-up of 4 months. The mean time to union was13.1 weeks and there3 patients developed radial nerve palsies in posterior approach group and one case in modified posterior approach postoperatively. <br /> <strong>Conclusion</strong>both approaches could be used in the management of humeral diaphyseal middle or distal third fractures, And the modified posterior approach confirmed by our results minimizes the complication rate, allow early return of full range of elbow motion and full triceps muscle power and facilitates early return to normal activities of the patient with excellent functional out comes .
https://smj.journals.ekb.eg/article_41805.html
https://smj.journals.ekb.eg/article_41805_36ccfc72ec24c1f47cf92151f8aec739.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
A Study of Prevalence of Obesity among Female Students in Sohag University
297
311
EN
Farida
S
Abdou
Department of Family Medicine, Faculty of Medicine, Sohag University.
ahmed
F
elnahhas
public health and community medicine department, faculty of medicine, Sohag University, sohag, egypt.
ahmed_hamed@med.sohag.edu.eg
Eman
R
Mohammed
Department of Family Medicine, Faculty of Medicine, Sohag University.
eman_mahmoud@med.sohag.edu.eg
Nesreen
Ali
Mohammed
department, of Public Health and Community Medicine-Sohag University.
nesreen_mohamed@med.sohag.edu.eg
10.21608/smj.2018.41810
<strong>Introduction</strong>: Obesity is a medical case in which extra body fat has stored to the extent that it may have a harmful effect on health. People are generally measured obese when their body mass index (BMI), ameasurement obtained by dividing aperson's weight by the square of the person's height, is over 30 kg/m2, with the range 25–30 kg/m2 defined as overweight. Some East Asian countries use lower values.<br /> <strong>Aim of the work: </strong>Find out the prevalence of overweight and obesity among female students in Sohag University, and identify important risk factors.<br /> <strong>Patients and Methods: </strong>Cross sectional study, included a sample of female students aged 17-25 in the selected faculties in Sohag University, the study was carried out in Faculty of Medicine, Faculty of Nursery and Faculty of Education in Sohag University, the questionnaire was divided into five parts, the demography, dietary habits, physical activity, perceptions of body weight and beliefs of obesity and the record of self-reported and actual anthropometric body measurements.<br /> <strong>Results: </strong>Overweight and obesity were prevalent among the our study subjects as the prevelance was 38.5%, lack of physical activity, soft drink consumpton and marital status were significantly associated with obesity, our students preferred dairy products and fatty foods over vegetables and fruits. In addition, their “lack of time” was the most frequently mentioned barrier to eating a healthy diet and engaging in regular exercise. Life style modification is important to improve healthy habits earlier in life. <br /> <strong>Conclusion: </strong>Overweight and obesity were prevalent among the our study subjects as the prevelance was 38.5%.
Obesity,Female,Sohag university
https://smj.journals.ekb.eg/article_41810.html
https://smj.journals.ekb.eg/article_41810_716cc8e1f291fee826818527c6594db3.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Study of Ankle-Brachial Index Compared to Carotid Intima-Media Thickness as a Non-Invasive Technique to Predict the Severity of Coronary Atherosclerosis
313
319
EN
Mohamed
H
Elsayed
Department of Internal Medicine. faculty of medicine.sohag University.
mohamed_elsayed@med.sohag.edu.eg
10.21608/smj.2018.41816
https://smj.journals.ekb.eg/article_41816.html
https://smj.journals.ekb.eg/article_41816_ffa444fcdef546504eec74f2e2723bdf.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Molecular characterization of mutation in the parC and gyrB genes that confer fluoroquinolone resistance in Streptococcus pneumonia isolates
321
334
EN
Laila
M
Yousef
Department of Clinical and Chemical pathology, Faculty of Medicine, Sohag University.
lailamohamed@med.sohag.edu.eg
Ghada
A
Ismael
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University.
Ashraf
k
Mohammed
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
ashraf_abdallah@med.sohag.edu.eg
Mohammed
H
Mahmoud
Department of Clinical Pathology, Faculty of Medicine, Sohag University.
mohamedhamdy@med.sohag.edu.eg
10.21608/smj.2018.41821
Resistance of Streptococcus pneumoniae to multiple antibacterial agents, including β-lactams, macrolides, tetracyclines, and co-trimoxazole, has emerged worldwide in the 1980s and 1990s and has emphasized the need for new therapeutic alternatives, such as newer fluoroquinolones. Older fluoroquinolones, such as ciprofloxacin and ofloxacin, have been widely used in the last 2 decades, but their activity against gram-positive pathogens is limited. Newer fluoroquinolones, such as levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin, have enhanced activity against most respiratory pathogens, and some are being more widely used to treat respiratory tract infections. Therefore, the emergence of fluoroquinolone-resistant S. pneumoniae strains, although worldwide prevalence is low, is a concern to clinicians who manage respiratory tract infections.<br /> <strong>Aim of the work: </strong>The aim of this study was to determine the prevalence of fluoroquinolone resistance Streptococcus pneumoniae (FQRSP) and to examine the genetic relatedness of pneumococcal isolates with parC and gyrB genes mutations in different specimens.<br /> <strong>Patients and Methods:</strong> In this study, Biometra Thermal Cyclar-T Gradient Software PCR system version 4 together with DNASIS 2.6 Sequence Analysis Programs were used to investigate the presence of mutations at quinolone resistance-determining regions of topoisomerase IV and DNA gyrase on 78 S. pneumoniae strains, Among 78 isolates 37 (47.4%) of S. pneumonia isolates were Fluroquinolones susceptible, 12 (15.4%) were with variable susceptibility and 29 (37.2%) were Fluroquinolones resistant.<br /> <strong>Results:</strong> Our study illustrate the role of mutation in the parC & gyrB genes and the effect of mutations in the both genes in fluoroquinolone resistance among S. pneumoniae isolates.<br /> <strong>Conclusion:</strong> Results indicated that there is a significant correlation between quinolone resistance development and mutations in the <em>parC </em>gene and in less significance in the <em>gyrB </em>genes .
GyrB,ParC,Streptococcus pneumonia,Fluoroquinolones
https://smj.journals.ekb.eg/article_41821.html
https://smj.journals.ekb.eg/article_41821_3a91a239a906032e4e7baefa9b4dcb62.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
MANAGEMENT OF SUPRACONDYLAR FRACTURE HUMERUS WITH Pink Pulseless Hand in Children.
337
341
EN
Mohamed
Atea
Department of Orthopedics, Sohag University ,Sohag , Egypt.
Ashraf
Rashad
Ahmed
Department of Orthopedics, Sohag University ,Sohag , Egypt.
ashraf_marzouk@med.sohag.edu.eg
Ahmed
I.
Eldosoky
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
ahmed_eldesouky@med.sohag.edu.eg
Mohamed
El saed
Abdel-Wanis
Department of Orthpaedic and Traumatology , Faculty of Medicine, Sohag University.
mohamed_abdelwanees@med.sohag.edu.eg
10.21608/smj.2018.41979
<span>The management of children with a pink pulseless hand in severely displaced supracondylar humeral fractures remains controversial regarding immediate exploration of the brachial artery and revascularization during fracture fixation or just closed reduction of the fracture and percutaneous pinning and follow up of limb perfusion.Between 2012 and 2016 we followed 52 children with displaced supracondylar fracture humerus. All patients had absent radial pulse with an otherwise well perfused hand. The radial pulse was returned in all patients, without surgical exploration after closed reduction of the fracture and percutaneous pinning .It takes variable periods from 1week to 2 months . Radial pulse recovery may be due to recanalization of brachial artery or by collaterals. So closed reduction of the fracture, percutaneous pinning and observation is a good option of treatment pediatric supracondylar humeral fractures with a pink pulseless hand without need to do early revascularization procedures.<br /> <br /> </span>
https://smj.journals.ekb.eg/article_41979.html
https://smj.journals.ekb.eg/article_41979_176a8d574753a55a5aeb9423e5124def.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
The use of modified humeral intramedullary interlocking nail in adolescent and elder children femoral shaft fracture
343
347
EN
Mohamed
Fath AL Din
Derar
Department of Orthopedic surgery, Faculty of Medicine, Sohag university.
Mohamed
Omar
Kenway
Department of Orthopedic surgery, Faculty of Medicine, Sohag university.
mohamed_ahmed8@med.sohag.edu.eg
Yasser
Mohmed
EL Sagher
Department of Orthopedic surgery, Faculty of Medicine, Sohag university.
Shazly
Saleh
Musa
Department of Orthopedic surgery, Faculty of Medicine, Sohag university.
shazli_mousa@med.sohag.edu.eg
10.21608/smj.2018.41980
https://smj.journals.ekb.eg/article_41980.html
https://smj.journals.ekb.eg/article_41980_d3e27a641c539e2fd327047415474f33.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Factors Affecting the Outcome in the Management of Cervicofacial Infection
349
355
EN
Mohammed
Kamal
Abbas
Department of surgery, Faculty of medicine, Sohag university.
Tarek
El Sayed
Ftohy
General Surgery Faculty of Medicine , Sohag university.
tarek_elsayed@med.sohag.edu.eg
Ahmed
Eisa
Ahmed
Department, of General Surgery , Faculty of Medicine, Sohag University
ahmed_ahmed2@med.sohag.edu.eg
Kamal
Hassanein
El-Sharkawy
Department of General Surgery, Faculty of Medicine, Sohag University.
kamal_mohamed@med.sohag.edu.eg
10.21608/smj.2018.42001
<strong><span style="text-decoration: underline;">Introduction</span></strong> Facial cellulitis and abscesses are common in public health problems and early recognition and management is critical, as they are becoming more severe with a noticeable increase in hospitalization. <strong><span style="text-decoration: underline;">Aim of work</span></strong> detection of factor affecting outcome in the management of cervicofacial infections and complication to reduce associated mortality and morbidity. <strong><span style="text-decoration: underline;">Patient and method</span></strong> This study was a prospective study which was conducted at Sohag University Hospital, General Surgery Department. It included patients with cervicofacial infection of odontogenic or non-odontogenic origin either localized or diffuse infection attended to at the Oral and Maxillofacial Surgery Clinic or the Accident and Emergency Unit from October 2016 to October 2017. <strong><span style="text-decoration: underline;">Results</span></strong> This study included 35 cases, the submandibular space was the most common single site affected (11-34.29%), followed by bilateral or multi- space involvement presented (13-37.14%) of study patients, Diabetes mellitus was the most common associated co- morbidity among study population (12-34.29%), and other systemic diseases (6-17.14%). <strong><span style="text-decoration: underline;">Conclusion</span> </strong>Diabetes, bad general condition, impaired laboratory parameters including an elevated blood sugar level and metabolic acidosis at time of admission were found to be significant risk factors for development of post intervention complications and/ or delayed recovery.
cervicofacial infection,deep neck space infection,DM,odontogenic infection,Trismus
https://smj.journals.ekb.eg/article_42001.html
https://smj.journals.ekb.eg/article_42001_f2e8de17883f0ec8b38a03b1d57eab47.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Oncoplastic breast surgery:current strategies and outcome
357
365
EN
Mahmoud
M.
Abd El Baky
Department of surgery, Faculty of medicine, Sohag university.
Ahmed
Abdelkahaar
Aldardeer
Department, of Surgery Faculty of, Medicine University of, Sohag.
ahmed_eldardeer@med.sohag.edu.eg
Ayman
M.
Ali
Department of surgery, Faculty of medicine, Sohag university.
ayman_ali@med.sohag.edu.eg
Alaa
A.
Redwan
Department, Faculty, of Medicine General Surgery, Sohag University.
profalaaredwan@yahoo.com
10.21608/smj.2018.42037
Oncoplastic surgery has emerged as a new approach to allow wide excision for breast conserving surgery without compromising the natural shape of the breast. It is based on integration of plastic surgery techniques for immediate breast reshaping after wide excision for breast cancer.<br /> <strong>Objective:</strong>To study the different methods of oncoplastic surgery for breast reconstruction to achieve better aesthetic outcome and improve quality of life.<br /> <strong>Patients and Methods:</strong> Thirty patients with breast cancer, treated at Sohag University Hospital between July 2016 to May 2017 were included in this study. The oncoplastic techniques performed were Local glandular tissue displacement in (60%), latissimus dorsi flap (LD) in (16.6%), superior pedicle flap in(10%), implant insertion in (6.6%) and Transverse rectus abdominus myocutanous flap (TRAM) in (6.6%). The choice of the oncoplastic techniques depends on the achievement of free safety margins, the breast volume, and its ptotic degree.<br /> <strong>Results:</strong> The number of patients included in the study were thirty. The median age was 43 years (range; 20–60 ys). There were three major complications that require repeating the oncoplastic techniques. Recorded complications included wound infection (5/30, 16.6 %) donor site seroma (10/30, 33.3 %), postoperative haematoma (1/30, 3.3%), flap ischemia and necrosis (1/30, 3.3%). The 12-months subjective patient satisfaction was excellent in 27 (90%) patients, and bad in 3 (10 %) patients. There were two local recurrence, no systemic metastasis after an average follow-up duration of 12 months.<br /> <strong>Conclusion:</strong>Restoring the defect after resection of the breast cancer can be safely achieved using oncoplastic procedures including the previous techniques with immediate breast reconstruction. In our patients, these procedures yield a satisfactory aesthetic outcome with lower morbidity.
Oncoplastic breast surgery,Breast conservative surgery,LD flap,TRAM flap
https://smj.journals.ekb.eg/article_42037.html
https://smj.journals.ekb.eg/article_42037_3492f2c01c5f4ce3e422143fe3a3eee4.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Microneedling as a monotherapy in treatment of male androgenetic alopecia
367
373
EN
ESSAMELDIN
ABDELAZIZ
NADA
0000-0003-0986-2486
DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university.
essameldin_nada@med.sohag.edu.eg
Reham
Ezz El-Dawla
El Sharkawy
Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
reham_elsharkawy@med.sohag.edu.eg
Wafaa
Mohamed
Abd El- Maged
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
wafaa_mohamed@med.sohag.edu.eg
Ashraf
Ahmed
Abd El-Latif
Department of Dermatology, Venereology and Andrology- Faculty of Medicine- Sohag University.
ashraf_abdelwahab@med.sohag.edu.eg
Marwa
A.
Abo Elmagd
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
marwaaly@med.sohag.edu.eg
10.21608/smj.2018.42045
https://smj.journals.ekb.eg/article_42045.html
https://smj.journals.ekb.eg/article_42045_1077226ee9d5f75e30faa2fa0374d1dd.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Association of osteopontin promoter polymorphism and aggresivness in breast cancer
375
379
EN
Madeha
M.
Zakhary
Department, of Medical Biochemistry, Faculty of Medicine, Assuit university.
Aida
A.
Mahmoud
Department, of Medical Biochemistry, Faculty of Medicine, Sohag university.
aida_mahmoud@med.sohag.edu.eg
Wael
B.
Ahmed
Department of General Surgery, Faculty of Medicine, Sohag university.
Marwa
shaaban
Hashim
Department of Biochemistry and microbiology, Facaulty of Medicine, Sohag University.
marwa_hashem@med.sohag.edu.eg
10.21608/smj.2018.42049
Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review The role of single-nucleotide polymorphism (SNP)-443 of the OPN gene in cancer aggressiveness.
https://smj.journals.ekb.eg/article_42049.html
https://smj.journals.ekb.eg/article_42049_6179996784565298af078fddbde59104.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Evaluation of some biomarkers in breast cancer patients
381
386
EN
Madeha
M.
Zakhary
Department OF Medical Biochemistry Faculty of Medicine. Assuit university.
Aida
A.
Mahmoud
Department, of Medical Biochemistry, Faculty of Medicine, Sohag university.
aida_mahmoud@med.sohag.edu.eg
Wael
B.
Ahmed
Department, OF General Surgery, Faculty of Medicine, Sohag university.
Marwa
shaaban
Hashim
Department of Biochemistry and microbiology, Facaulty of Medicine, Sohag University.
marwa_hashem@med.sohag.edu.eg
10.21608/smj.2018.42078
<strong>Background</strong>. Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes onco-genic features including cell proliferation, survival, migration, and angiogenesis. Here, we analyzed the correlation between the expression pattern of (osteopontin and CA15.3) and clinic-pathological status of breast cancer and other standard prognostic factors.<br /> <strong>Patients and methods</strong>. A case control study with 60 female breast cancer patients and 20 controls. All patients were subjected to complete medical history uptake , clinical examination and laboratory investigations include histopathological type of cancer, hormone receptor status ,CA 15-3 serum concentratios and osteopontin plasma level by ELISA.<br /> <strong>Results. </strong>Our study showed that osteopontin plasma level was significantly different among breast cancers and controls (p<0.0001) but no association between osteopontin plasma level and histological type , stage or grade. Also we found significant association between CA 15-3 and cancer stage (p<0.000). Interestingly CA15.3 serum concentrations increased in hormone receptor positive cancer.<br /> <strong>Conclusion. </strong>OPN and CA15.3 are overexpressed in breast cancer. OPN overexpression is associated with poor prognosis. Moreover CA15.3 has minimal prognostic value in non metastatic breast cancer.
https://smj.journals.ekb.eg/article_42078.html
https://smj.journals.ekb.eg/article_42078_a27a9b54f154efc5297ab95b75239b5b.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Topical dutasteride with microneedling in treatment of male androgenetic alopecia
387
400
EN
ESSAMELDIN
ABDELAZIZ
NADA
0000-0003-0986-2486
Department, OF DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university.
essameldin_nada@med.sohag.edu.eg
Reham
Ezz El-Dawla
El Sharkawy
Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
reham_elsharkawy@med.sohag.edu.eg
Wafaa
Mohamed
Abd El- Maged
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
wafaa_mohamed@med.sohag.edu.eg
Marwa
A.
Abo Elmagd
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
marwaaly@med.sohag.edu.eg
10.21608/smj.2018.42083
https://smj.journals.ekb.eg/article_42083.html
https://smj.journals.ekb.eg/article_42083_24b61cbba4be9982db23c318414034c0.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Nerve growth factor (NGF) expression in correlation with severity of pruritus in cirrhotic patients
403
410
EN
ESSAMELDIN
Abd El-Aziz
NADA
0000-0003-0986-2486
DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university.
essameldin_nada@med.sohag.edu.eg
Hanan
Abd El Rady
Assaf
Department of Dermatology, Venereology and Andrology, Sohag Faculty of Medicine, Sohag University.
hanan_asaf@med.sohag.edu.eg
Reham
Ezz El-Dawla
El Sharkawy
Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
reham_elsharkawy@med.sohag.edu.eg
Amr
Mohamed
Zaghloul
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University.
amr_hashem@med.sohag.edu.eg
Marwa
Mohamed
Abd El Meged
Department of Dermatology, Venereology and Andrology, Sohag Faculty of Medicine, Sohag University.
Mahmoud
Rezk
Abd El Wahed
Department of pathology, Assuit Faculty of Medicine, Assuit University.
Asmaa
Mahmoud
Ahmed
Department of pathology, Assuit Faculty of Medicine, Assuit University.
10.21608/smj.2018.42251
<strong>Background:</strong>Hepatic pruritus is a very common symptom among different chronic liver diseases, particularly in those related to cholestasis. Its prevalence is variable among liver diseases, ranging from 5% in chronic hepatitis C virus infection to 70% in primary biliary cirrhosis. Its etiopathogenesis remains poorly understood.Nerve growth factor (NGF) is a member of neurotrophins. many studies clearly demonstrate their role in pruritus. Nerve growth factor (NGF) is overexpressed in prurigonodularis and its therapeutic administration is pruritogenic. In atopic dermatitis, NGF is released by keratinocytes, mast cells and fibroblasts and plasma levels of NGF are also elevated and correlate with disease activity.This study examines the hypothesis that expression of NGF protein is altered in cirrhotic patients with pruritus.<br /> <strong>Patients and Methods: </strong>To test our hypothesis, we examined the expression patterns of NGF protein in cirrhotic patients with pruritus, cirrhotic patients without pruritus and corresponding healthy (control). skin biopsies (20 specimens each) were evaluated using immunoperoxidase staining techniques.<br /> <strong>Results: </strong>We found variations between the skins of cirrhotic patients with and without pruritus and healthy skin. In healthy skin, the expression of NGF protein was strong (basal cell keratinocytes), moderate (spinouslayer), and weak or abscent (granular cell layer). In contrast, marked expression of NGF protein was observed in all layers of skin (total NGF epidermis and dermis) incirrhotic patients with pruritus in comparison with cirrhotic patients without pruritus and healthy control and this was statistically significant. NGF protein expression was strong (basal cell keratinocytes), moderate (spinous layer), and weak or abscent (granular cell layer). The expression of NGF protein was strong in the adnexal structures.<br /> <strong>Conclusions: </strong>We report, for the first time, increased expression of NGF protein in the epidermal keratinocytes of cirrhotic patients with pruritus skin. Our findings suggest possible roles for this protienin pathophysiology of hepatic pruritus. The clinical ramifications of these observations mandate further investigations.
https://smj.journals.ekb.eg/article_42251.html
https://smj.journals.ekb.eg/article_42251_fe116eb3b70a0cd3c5fe26915e705197.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Gut microbiome in chronic kidney disease
415
420
EN
Noher
Mohammad
Abass
Department of Internal Medicine, Sohag Faculty of Medicine, Sohag University.
nahirmohamed@med.sohag.edu.eg
10.21608/smj.2018.42518
https://smj.journals.ekb.eg/article_42518.html
https://smj.journals.ekb.eg/article_42518_b99dc76e0f8a486f978232d8936a6abe.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Study of Pulmonary Hypertension in Hemodialysis patients in Sohag University Hospital
423
429
EN
Lotfy
Hamed
Abo Dahab
Department of Internal Medicine, Faculty of Medicine, Sohag University.
loutfy_abodahab@med.sohag.edu.eg
Ahmed
Mohamed
Boghdady
Department of Internal Medicine, Faculty of Medicine, Sohag University.
ahmed_boghdady@med.sohag.edu.eg
Nayel
Abd ELhameed
Zaki
Department of Internal Medicine, Faculty of Medicine, Sohag University.
nail_elsaghier@med.sohag.edu.eg
Noher
Mohammad
Abass
Department of Internal Medicine, Sohag Faculty of Medicine, Sohag University.
nahirmohamed@med.sohag.edu.eg
10.21608/smj.2018.42519
https://smj.journals.ekb.eg/article_42519.html
https://smj.journals.ekb.eg/article_42519_88372dc5ac53e1833f2b20041083daac.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Review on Collection , Preservation and Fowarding of Biological Samples for Toxicological Analysis
431
438
EN
Maha
Abd-Elhamed
Hilal
Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Sohag, University.
maha_abdelaziz@med.sohag.edu.eg
Essam
M.
Abdullah
Lecturer of Forensic Medicine & Clinical Toxicoogy, Faculty of Medicine - Sohag University.
essam_abdallah@med.sohag.edu.eg
Reda
M
El Sayed
Department of, Forensic Medicine & Clinical Toxicology Faculty of Medicine, Sohag University, Egypt.
reda_abdelrasowl@med.sohag.edu.eg
Hend
M.
Salman
Demonstrator in the Department of Forensic Medicine & Clinical Toxicoogy, Faculty of Medicine - Sohag University.
hend-mohamed@med.sohag.edu.eg
10.21608/smj.2018.42520
Forensic Toxicology is the study and practice of the application of toxicology to the purposes of the law. The relevance of any finding is determined, in the first instance, by the nature and integrity of the specimen(s) submitted for analysis. This means that there are several specific challenges to select and collect specimens for <em>ante-mortem</em>
and <em>post-mortem </em>toxicology investigation. <em>Post-mortem </em>specimens may be numerous and can endow some special difficulties compared to clinical specimens, namely those resulting from autolytic and putrefactive changes. Storage stability is also an important issue to be considered during the pre-analytic phase, since its consideration should facilitate the assessment of sample quality and the analytical result obtained from that sample. The knowledge on degradation mechanisms and methods to increase storage stability may enable the forensic toxicologist to circumvent possible difficulties. Therefore, advantages and limitations of specimen preservation procedures are thoroughly discussed in this review. Presently, harmonized protocols for sampling in suspected intoxications would have obvious utility. In the present review an overview is given on sampling procedures for routinely collected specimens as well as on alternative specimens that may provide additional information on the route and timing of exposure to a specific xenobiotic. Last, but not least, how to forward a correct report and how to interpret a toxicological results is provided. This comprehensive review article is intented as a significant help for forensic toxicologists to accomplish their frequently overwhelming mission.
sampling,collection,Preservation,toxicological analysis
https://smj.journals.ekb.eg/article_42520.html
https://smj.journals.ekb.eg/article_42520_ad2abd4b3401991089c172c5604e19f1.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Evaluation of cardiac function in patients with thalassemia intermedia: A prospective hospital based study
439
444
EN
Alzahraa
Alsayed
Ahmed
Department of Pediatric haematology Unit, Pediatric Department,Faculty of Medicine, Sohag University, Sohag, Egypt.
elzahraa_sharaf@med.sohag.edu.eg
Safaa
Husein
Ali
Department of Pediatric , Faculty of Medicine,Sohag University, Sohag, Egypt.
safaa_ahmed@med.sohag.edu.eg
Walaa
Mostafa
Madkoor
Department of Pediatric ,Faculty of Medicine, Sohag University, Sohag Egypt.
10.21608/smj.2018.42525
<strong>Background</strong><strong>:</strong>B-Thalassemia is an inherited hemoglobin disorder caused by impaired synthesis of the b-globin chain and resulting in chronic hemolytic anemia.In the absence of regular treatment of thalassemia intermedia patients the diastolic performance of the left ventricle is maintained stable, while the pressure of pulmonary arteries continues to rise which is the main cause of death in these patients. 2D, M mode echocardiographyand tissueDopplerare method for evaluating the cardiac function in patients with thalassemia intermedia.<br /> <strong>Objective</strong>: Our main objective in this study is to evaluate the cardiac function in patients with thalassemia intermedia by 2D, M mode echocardiography and Doppler methods.<br /> <strong>Methods: </strong>This case-control study was conducted on 46 thalassemic patients (mean age: 9.7 ± 4.6years) and 46 healthy individuals (mean age: 10.3 ± 4.1 years) as a control group from October 2016 toSeptember 2017 in the Pediatric haematology Clinics and inpatients of Pediatric Department.There was no sign of cardiac involvement by physical examination, chest x-ray and ECG in patients. Echocardiographic parameters were measured in groups, and finally data was analyzed by SPSS software.<br /> <strong>Results:</strong>The mean of left ventricular myocardial performance index (LMPI) ((P- value<0.001) and left ventricular mass index (LVMI) ((P- value<0.001) have statistically significant differencebetween two groups. Mean of interventricular septal dimension in diastole (IVSD), left ventricular posterior wall thickness in diastole (LVPWD) and interventricular septal dimension in systole (IVSS) were also statistically significant with a P-value of, <0.001, 0.042, 0.05).<br /> <strong>Conclusion</strong><strong>: </strong>the systolic and diastolic performance of thalassemia intermedia patients is affected earlier in comparison with control group in some parameters including LVMPI, EF, FS, IVSD, IVSS, LVPWDD and RVMPI. For more evaluation, more quantitative and comprehensive research suggested by evaluation of specific effective factors to psychosocial health of these patients.<br /> <strong>Study Limitation</strong><br /> * Age group: we conduct only the pediatric age group thalassemia intermedia, and as we know the most of complication appear in older age<br /> * Number of patient: we conduct only46 patient in our study.<br /> *Lack of material potential: availability of other facilities like T* and MRI as echocardiography is not able to replace them even echocardiographic abnormalities are found.
thalassemia intermedia in children,Complications of TI,cardiac function,echocardiography and Dopplerstudies
https://smj.journals.ekb.eg/article_42525.html
https://smj.journals.ekb.eg/article_42525_5d882dc5bb636b5dceefbb41cf213bbc.pdf
Sohag University; Faculty of Medicine
Sohag Medical Journal
1687-8353
2682-4159
22
1
2018
01
01
Histopathological evaluation of skin in cirrhotic patients with pruritus
447
452
EN
ESSAMELDIN
ABDELAZIZ
NADA
0000-0003-0986-2486
DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university.
essameldin_nada@med.sohag.edu.eg
Hanan
AbdlRadi
Assaf
Department of Dermatology, Venereology and Andrology, Sohag Faculty of Medicine, Sohag University.
hanan_asaf@med.sohag.edu.eg
Reham
Ezz El-Dawla
El Sharkawy
Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University.
reham_elsharkawy@med.sohag.edu.eg
Amr
Mohamed
Zaghloul
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University.
amr_hashem@med.sohag.edu.eg
Marwa
Mohamed
Abd El Meged
Department of Dermatology, Venereology and Andrology, Sohag Faculty of Medicine, Sohag University.
marwamohamed@med.sohag.edu.eg
Mahmoud
Rezk
Abd El Wahed
Department of pathology, Assuit Faculty of Medicine, Assuit University.
Asmaa
Mahmoud
Ahmed
Department of pathology, Assuit Faculty of Medicine, Assuit University.
10.21608/smj.2018.42529
<strong>Background: </strong>Cirrhosis often is a silent disease Clinical symptoms at presentation may include jaundice of the eyes or skin, pruritus, gastrointestinal bleeding, coagulopathy, increasing abdominal girth, and mental status changes. Pruritus may be the presenting symptom, arising years before any other classic clinical and laboratory markers of hepatic dysfunction. This study examines the clinical, laboratory and histopathological changes in the skins of cirrhotic patients with pruritus in comparison with cirrhotic patients without pruritus and healthy control skins .<br /> <strong>Patients and Methods<span style="text-decoration: underline;">:</span> </strong>To evaluate clinical, laboratory and histopathological changes in cirrhotic patients with pruritus, cirrhotic patients without pruritus and corresponding healthy (control). skin biopsies (20 specimens each) using hematoxylin and eosin stain and to study mast cell density using gimesa stain.<br /> <strong>Results: </strong>In the skin biopsy specimens of the cirrhotic patients with pruritus we found several histological changes including: epidermal hyperplasia (acanthosis) ,vascular ectasia(dilated dermal blood vessels), hypertrophied dermal nerve endings, mixed inflammatory cellular infilterate and lymphocytic vasculopathy (swelling of the endothelial cell lining of the blood vessels without fibrinoid necrosis, leucocytoclasia or extravasation of red blood cells). Evaluation of mast cell count in Gimesa stained skin sections revealed an increased numbers of these cells in the group of cirrhotic patients with pruritus ( N=5-10). The cells noted in perivascular, perineural and interstitial distribution (between collagen bundles).<br /> <strong>Conclusions<span style="text-decoration: underline;">:</span> </strong>We report, for the first time, some histopathologial changes in the skins of cirrhotic patients with pruritus in comparison with cirrhotic patients without pruritus and healthy control skins .
https://smj.journals.ekb.eg/article_42529.html
https://smj.journals.ekb.eg/article_42529_fa33077822e6f05ca719099bdc318829.pdf